Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO Study.

Background And Aims: Type 2 diabetes mellitus (DM) has a high prevalence in aging obese postmenopausal women. It is not clear whether or not diabetes produces an increase in bone mineral density or an increase in fracture rates.

Objective: The main objective of this study was to investigate whether type 2 DM produces a higher prevalence of vertebral, hip and non-vertebral fractures in obese postmenopausal Caucasian women.

Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from the GIUMO Study Group.

Although the negative effect of systemic steroids on bone is well documented, there is not clear evidence about possible adverse effects of inhaled steroids on bone metabolism and fractures. A cross-sectional study was performed on 105 women suffering from bronchial asthma treated with inhaled steroids and 133 controls. Bone mineral density (BMD) was measured by quantitative ultrasonography (QUS) at the calcaneus and by dual X-ray absorptiometry (DXA), at both the lumbar spine and proximal femur.

[What is the opinion of Spanish internists on osteoporosis?].

Objective: To conduct an opinion survey on osteoporosis in Spanish internists.

Method: Survey sent by mail and by personal visit to members of the Spanish Internists Society. Collection of data on opinion on the disease, diagnostic and therapeutic attitude and means available (general laboratory analyses, conventional radiology, biochemical markers of bone remodeling, densitometry and ultrasounds) and preference when choosing a certain treatment.

[Clinical and therapeutic characteristics in patients with heart failure cared in a tertiary hospital].

Introduction: Heart failure shows high incidence and prevalence in our population. Objectives of our study are to describe the profile of patients cared in the Internal Medicine Department of our hospital, in order to analyze the therapeutic characteristics and to know the degree of utilization of different pharmacological groups.

Patients And Methods: A cross-sectional study with collection of data from clinical records of patients admitted to 2002 with the diagnosis of heart failure in Internal Medicine Department of San Carlos Hospital in Madrid.

[Calcaneous ultrasonography as measurement of osteoporosis prevalence in the general population in relation to the diagnostic criterion utilized. Data of the study GIUMO].

Context: In recent years, a large number of techniques have been developed to estimate the bone mineral density for the diagnosis of osteoporosis. However, diagnostic criteria established by WHO are invariably applied for the interpretation of dual radiological densitometry (DEXA), which could not be correct in the case of the interpretation of ultrasound.

Method: We studied 2,589 randomly chosen people of both sexes, 1,138 males and 1,451 women from 10 to 99 years, in 11 spanish provinces.

[Double-blind study on the efficacy of long-term intermittent nasal elcatonin in recent postmenopausal women].

Fundamentals: Continuous treatment with calcitonin (CT) has caused an increase of bone mineral density for the first 18 months, followed by a partial decrease of it. In order to obtain a better result in a two year follow-up, it is proposed a schedule treatment during 50% to 66% of the time in recent postmenopausal women.

Methods: Pilot, double-blind, randomised, two years follow-up study.

[Bone mineral density in juvenile-onset diabetes mellitus].

Objective: To determine bone mineral density (BMD) at axial and appendicular sites in patients with type 1 diabetes mellitus and evaluate its relationship with metabolic control and disease duration.

Patients And Methods: BMD was measured by dual-energy X-ray absorptiometry (Hologic QDR-1000) in the lumbar spine (L1-L4) and at the distal third forearm in 246 healthy non-diabetic children and adolescents (111 boys, 135 girls, aged 2.8-20.

[Forearm bone mineral density in healthy children].

Objective: In order to establish the normal patterns of forearm bone mineral density (BMD), BMD in the cortical and trabecular parts of the distal forearm were studied in a normal pediatric population.

Patients And Methods: BMD was measured by dual-energy X-ray absorptiometry (HOLOGIC QDR-1000) in the distal third forearm of 246 normal children and adolescents (111 boys and 135 girls) ranging from 2.8 to 20.

[Comparative study of bone mineralization in children and adolescents with familial short stature and a control group].

Objective: Our objective was to study children with familial short stature (FSS) to observe whether they develop bone mineralization similar to that seen in healthy children with an adequate height for their age and sex.

Patients And Methods: The study included 70 FSS patients (39 boys and 31 girls) between 6 and 20 years of age and 246 control patients with the same mean age and sex of the study group. Bone mineral density was measured in the lumbar spine and forearm by performing dual energy X-ray absorptiometry using a Hologic ADR-1000.

[Comparative study of bone mass in various places in patients with osteoporosis].

Radiogrametric values of the second right metacarpal and data obtained by radiographic densitometry in the lumbar cord and the neck of the right femur have been studied comparatively in sixty two women and 6 men, with ages within 24 and 82 years and suspicion of suffering osteoporosis. Cases have been divided into four groups depending on the presence of vertebral fractures (Group I) and the densitometric results at the level of the lumbar cord. The comparison has shown a poor correlation between lumbar densitometric values and the radiogrametry, both in the cases considered normal and pathogenic.