Development of a stakeholder-engaged tool to evaluate community convening and promote community health.

Background: Health systems support community health and well-being, and while many commit resources to convening in support of community-engaged communication interventions, they currently lack tools to evaluate this effort. This report describes one health system's mixed-methods stakeholder-engaged development of robust yet pragmatic convening assessment tools.

Methods: Semi-structured interviews and web surveys with key stakeholders informed a taxonomy of quality convening and accompanying survey tool.

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn.

Monoclonal antibody (mAb) engineering that optimizes binding to receptors present on brain vascular endothelial cells has enabled them to cross through the blood-brain barrier (BBB) and access the brain parenchyma to treat neurological diseases. However, once in the brain the extent to which receptor-mediated reverse transcytosis clears mAb from the brain is unknown. The aim of this study was to determine the contribution of the neonatal Fc-receptor (FcRn) in rat brain efflux employing two different in vivo drug delivery models.