Publications by authors named "Low Jiali"

Article Synopsis
  • Patients with advanced non-small-cell lung cancer (NSCLC) and brain metastases are often treated with osimertinib, but the effectiveness of adding stereotactic radiosurgery (SRS) is uncertain.
  • This study proposes a meta-analysis of existing trials to determine if SRS combined with osimertinib improves control of brain metastases compared to osimertinib alone.
  • The research will evaluate various outcomes, including intracranial progression-free survival and overall survival, and will be shared with the medical community and patients through publications and presentations.*
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Importance: The Cancer and Aging Research Group (CARG) prediction model for chemotherapy-related toxic effects has been developed but not yet validated in older Asian adults. In view of differences in drug metabolism and toxic effect reporting in the Asian population, the ability of this tool to guide the cancer treatment decision-making process in older Asian adults needs to be assessed.

Objective: To examine the validity of the CARG predictive model in a multiethnic Asian cohort of older adults.

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Background: Atypical response patterns have been a topic of increasing relevance since the advent of immune checkpoint inhibitors (ICIs), challenging the traditional RECIST (Response Evaluation Criteria in Solid Tumors) method of tumor response assessment. Newer immune-related response criteria can allow for the evolution of radiologic pseudoprogression, but still fail to capture the full range of atypical response patterns encountered in clinical reporting.

Methods: We did a detailed lesion-by-lesion analysis of the serial imaging of 46 renal cell carcinoma (RCC) patients treated with ICIs with the aim of capturing the full range of radiologic behaviour.

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