Evidence for the extracellular reduction of ferricyanide by rat liver. A trans-plasma membrane redox system.

1. Reduction of ferricyanide by the isolated perfused rat liver and by isolated rat hepatocytes was studied. 2.

Role of aerobic conditions in the control of cell proliferation.

Our experiments demonstrate that proliferation of human lymphocytes as well as fibroblasts is inhibited by oxygen. It is not a toxic effect and it has been possible to find an intermediary link in intracellular glycolysis, oxidate metabolism, or macromolecule synthesis. Accessory cells may reduce the inhibitory action of oxygen, thereby exerting an influence on the growth rate.

Action of caerulein, gastrin 17, pentagastrin, and secretin on the active transport of sodium by the frog skin.

Frog skin was mounted in an Ussing chamber and the actions of caerulein, gastrin, pentagastrin, and secretin on the active transport of sodium were studied using the short-circuit current method. All polypeptides exerted their effect when placed in the solution bathing the outside surface of the skin. The response was a transient dose-related increase in the transepithelial electrical potential difference and in the short-circuit current.

Testosterone, aggression, physical, and personality dimensions in normal adolescent males.

Fifty-eight normal adolescent Swedish boys, aged 16, provided two sets of blood samples for plasma testosterone assays as well as data on a number of personality inventories and rating scales assessing aggression, inpulsiveness, lack of frustration tolerance, extraversion, and anxiety. Physical variables such as pubertal stage, height, weight, chest circumference, and physical strength were measured. There was a significant association (r = 0.

Preoperative localization of aldosterone-producing adenomas. An analysis of the efficiency of different diagnostic procedures made from 11 cases and from a review of the literature.

The efficiency of six different methods available for topographical diagnosis of primary aldosteronism was analysed in retrospect from 11 surgically verified cases and by an analysis of 360 cases reported in the literature. Differentiation between hyperplasia and adenoma was most safely predicted by monitoring the diurnal rhythm of plasma aldosterone and its reaction to posture. Adrenal vein catheterization with aldosterone determinations was helpful in establishing the presence of hyperplasia in approximately 70% of these cases.

Effect of somatomedin A and insulin on cyclic AMP generation in isolated rat hepatocytes.

Insulin and somatomedin A were shown to have inhibitory action on glucagon stimulated but not basal cyclic AMP production in isolated rat hepatocytes. The inhibition was dose-dependent and the potency per mol was about 100 fold higher for insulin than for somatomedin A.

Ketotic hypoglycemia of childhood--a clinical trial of several unifying etiological hypotheses.

We have studied 15 children referred to St. Göran's Children's Hospital because of suspected ketotic hypoglycemia. The patients were investigated according to a program designed to test several hypotheses--old and new--postulated to explain the etiology of ketotic hypoglycemia.

Infection of cardiac suture line after ventricular aneurysmectomy. Report of two cases.

Two cases of sepsis following ventricular aneurysmectomy are presented. In both, the source of sepsis was an infected caridac suture line in which Teflon felt strips were used to reinforce the closure. One patient had a pseudoaneurysm and a chronic empyema of the left side of the chest, and the second had a ventriculocutaneous fistula.

Uptake and release of immunoreactive insulin in coronary circulation in man: studies at rest, during exercise, and during glucose and insulin infusions.

Significant uptake and release of immunoreactive insulin by the heart have been observed in man, and this is related to plasma insulin levels. Exercise and the fed state appear to affect the myocardial handling of insulin. The findings could not be related to myocardial carbohydrate metabolism, but could, during exercise, be related to myocardial lipid metabolism.

Fluorescence-detected magnetic circular dichroism of fluorescent and nonfluorescent molecules.

We have modified a spectrometer for the measurement of fluorescence-detected magnetic (and natural) circular dichroism (FDMCD). The instrument can be operated either in a direct mode in which the average and polarization-induced differential fluorescent intensities are recorded separately or in a mode which records their ratio. We have measured the FDMCD of tryptophan, which is itself fluorescent.