Publications by authors named "Lovis C"

The essence of language and its evolutionary determinants have long been research subjects with multifaceted explorations. This work reports on a large-scale observational study focused on the language use of clinicians interacting with a phrase prediction system in a clinical setting. By adopting principles of adaptation to evolutionary selection pressure, we attempt to identify the major determinants of language emergence specific to this context.

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Background: Prompt engineering, focusing on crafting effective prompts to large language models (LLMs), has garnered attention for its capabilities at harnessing the potential of LLMs. This is even more crucial in the medical domain due to its specialized terminology and language technicity. Clinical natural language processing applications must navigate complex language and ensure privacy compliance.

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Dolodoc is a mobile application aimed at improving autonomy and quality of life for individuals living with chronic pain. Designed as a virtual coach, it offers counseling according to 7 important dimensions of quality of life. Activities, pain and fulfillment of the 7 dimensions of quality of life can be recorded in the application.

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Electrocardiogram (ECG) is one of the reference cardiovascular diagnostic exams. However, the ECG signal is very prone to being distorted through different sources of artifacts that can later interfere with the diagnostic. For this reason, signal quality assessment (SQA) methods that identify corrupted signals are critical to improve the robustness of automatic ECG diagnostic methods.

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Article Synopsis
  • NER models using Transformers have become popular for their performance across different languages and fields, but differences in how they evaluate tokens versus entities are often ignored.
  • This study focuses on French oncological reports, fine-tuning four BERT-based models to classify tokens and assess their performance at both token and entity levels.
  • Results show significant discrepancies in effectiveness between the two evaluation methods and indicate that while BERT outperforms ChatGPT in recognizing complex entities in French, comprehensive evaluation approaches are crucial in NER tasks.
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Generative Large Language Models (LLMs) have become ubiquitous in various fields, including healthcare and medicine. Consequently, there is growing interest in leveraging LLMs for medical applications, leading to the emergence of novel models daily. However, evaluation and benchmarking frameworks for LLMs are scarce, particularly those tailored for medical French.

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The goal of this paper is to build an automatic way to interpret conclusions from brain molecular imaging reports performed for investigation of cognitive disturbances (FDG, Amyloid and Tau PET) by comparing several traditional machine learning (ML) techniques-based text classification methods. Two purposes are defined: to identify positive or negative results in all three modalities, and to extract diagnostic impressions for Alzheimer's Disease (AD), Fronto-Temporal Dementia (FTD), Lewy Bodies Dementia (LBD) based on metabolism of perfusion patterns. A dataset was created by manual parallel annotation of 1668 conclusions of reports from the Nuclear Medicine and Molecular Imaging Division of Geneva University Hospitals.

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Heart failure is the leading reason for seniors being admitted to hospitals. Over half of the elderly individuals diagnosed with heart failure find themselves readmitted to hospitals within a span of six months. This recurrence is associated with inadequate adherence to medical treatment and recommendations, underscoring the necessity for support systems that aid seniors in better adhering to post-hospitalization instructions.

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Automatic extraction of body-text within clinical PDF documents is necessary to enhance downstream NLP tasks but remains a challenge. This study presents an unsupervised algorithm designed to extract body-text leveraging large volume of data. Using DBSCAN clustering over aggregate pages, our method extracts and organize text blocks using their content and coordinates.

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Representing numeric values such as scalars holds great importance for accurately depicting clinical data. While the result value itself will always be represented using an integer, decimal, or other scalar format, it needs to be linked to its corresponding data element. In SNOMED CT, as in most other terminology systems, this is done through an attribute relationship.

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Radiology reports contain crucial patient information, in addition to images, that can be automatically extracted for secondary uses such as clinical support and research for diagnosis. We tested several classifiers to classify 1,218 breast MRI reports in French from two Swiss clinical centers. Logistic regression performed better for both internal (accuracy > 0.

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Similarity and clustering tasks based on data extracted from electronic health records on the patient level suffer from the curse of dimensionality and the lack of inter-patient data comparability. Indeed, for many health institutions, there are many more variables, and ways of expressing those variables to represent patients than patients sharing the same set of data. To lower redundancy and increase interoperability one strategy is to map data to semantic-driven representations through medical knowledge graphs such as SNOMED-CT.

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The future of a machine writing our reports for us could also lead to it carrying out our consultations, a scenario whose relevance is open to debate. Nevertheless, the present offers us new artificial intelligence tools that can support us in our daily activities. The publication in 2017 of Transformers initiated a disruptive revolution by enabling the emergence of major language models, of which ChatGPT is the best known.

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Background: Informed consent is one of the key principles of conducting research involving humans. When research participants give consent, they perform an act in which they utter, write or otherwise provide an authorisation to somebody to do something. This paper proposes a new understanding of the informed consent as a compositional act.

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The realm of health care is on the cusp of a significant technological leap, courtesy of the advancements in artificial intelligence (AI) language models, but ensuring the ethical design, deployment, and use of these technologies is imperative to truly realize their potential in improving health care delivery and promoting human well-being and safety. Indeed, these models have demonstrated remarkable prowess in generating humanlike text, evidenced by a growing body of research and real-world applications. This capability paves the way for enhanced patient engagement, clinical decision support, and a plethora of other applications that were once considered beyond reach.

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Background: Information overflow, a common problem in the present clinical environment, can be mitigated by summarizing clinical data. Although there are several solutions for clinical summarization, there is a lack of a complete overview of the research relevant to this field.

Objective: This study aims to identify state-of-the-art solutions for clinical summarization, to analyze their capabilities, and to identify their properties.

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Article Synopsis
  • * A literature search revealed 107 relevant articles, identifying six main barriers, such as data concerns and ethical issues, and five key facilitators, including clinical impact and evaluation methods.
  • * The findings emphasize the importance of a collaborative approach in designing and deploying AI solutions to improve breast cancer diagnosis in clinical settings.
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Objectives: The objective of this study is the exploration of Artificial Intelligence and Natural Language Processing techniques to support the automatic assignment of the four Response Evaluation Criteria in Solid Tumors (RECIST) scales based on radiology reports. We also aim at evaluating how languages and institutional specificities of Swiss teaching hospitals are likely to affect the quality of the classification in French and German languages.

Methods: In our approach, 7 machine learning methods were evaluated to establish a strong baseline.

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Background: Implementation of digital health technologies has grown rapidly, but many remain limited to pilot studies due to challenges, such as a lack of evidence or barriers to implementation. Overcoming these challenges requires learning from previous implementations and systematically documenting implementation processes to better understand the real-world impact of a technology and identify effective strategies for future implementation.

Objective: A group of global experts, facilitated by the Geneva Digital Health Hub, developed the Guidelines and Checklist for the Reporting on Digital Health Implementations (iCHECK-DH, pronounced "I checked") to improve the completeness of reporting on digital health implementations.

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Article Synopsis
  • Two COVID-19 outbreaks in Switzerland in 2020 led to changes in treatment approaches based on new medical evidence, with a study focusing on patient outcomes during these waves.
  • A total of 2,983 hospitalized patients were analyzed, finding similar in-hospital mortality rates between the first wave (16.3%) and the second wave (16.0%), but notable differences in ICU admissions and treatments used.
  • During the second wave, fewer patients were admitted to the ICU but had higher mortality rates; corticosteroids became the main treatment compared to previous use of medications like hydroxychloroquine, leading to a 25% reduction in mortality risk overall during the second wave.
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Introduction: Drug utilization is currently assessed through traditional data sources such as big electronic medical records (EMRs) databases, surveys, and medication sales. Social media and internet data have been reported to provide more accessible and more timely access to medications' utilization.

Objective: This review aims at providing evidence comparing web data on drug utilization to other sources before the COVID-19 pandemic.

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JMIR Medical Informatics is pleased to offer implementation reports as a new article type. Implementation reports present real-world accounts of the implementation of health technologies and clinical interventions. This new article type is intended to promote the rapid documentation and dissemination of the perspectives and experiences of those involved in implementing digital health interventions and assessing the effectiveness of digital health projects.

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Background: We assessed potential consent bias in a cohort of > 40,000 adult patients asked by mail after hospitalization to consent to the use of past, present and future clinical and biological data in an ongoing 'general consent' program at a large tertiary hospital in Switzerland.

Methods: In this retrospective cohort study, all adult patients hospitalized between April 2019 and March 2020 were invited to participate to the general consent program. Demographic and clinical characteristics were extracted from patients' electronic health records (EHR).

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Background: Clinical decision support systems (CDSS) can help identify drug-related problems (DRPs). However, the alert specificity remains variable. Defining more relevant alerts for detecting DRPs would improve CDSS.

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