Face to face: The eyes as an anchor in multimodal communication.

Making eye contact with our conversational partners is what is most common in multimodal communication. Yet, little is known about this behavior. Prior studies have reported different findings on what we look at in the narrator's face.

Gel instillation sonohysterography (GIS) using Endosgel versus ExEmgel, comparison of pain and image quality and cost benefit analysis: A double blind randomised controlled trial. GISPAIN trial.

Introduction: Pain experience, physical reaction, image quality and adverse events during Gel Instillation Sonohysterography (GIS) can differ using gels with different compositions. As a result, patient satisfaction can also be affected. The effect of two instillation gels, Endosgel versus ExEmgel, using both the Visual Analogue Scale (VAS) and a Continuous Pain Score Meter (CPSM) was therefore compared.

Information thermodynamics of transition paths between multiple mesostates.

A central concern across the natural sciences is a quantitative understanding of the mechanism governing rare transitions between two metastable states. Recent research has uncovered a fundamental equality between the time-reversal asymmetry of the ensemble of such transition paths and the informativeness of system dynamics about the reactivity of a given trajectory, immediately leading to quantitative criteria for judging the importance of distinct system coordinates for the transition. Here we generalize this framework to multiple mesostates.

Measuring transformative virtual reality experiences in children's drawings.

Transformative experiences in an individual's life have a lasting impact on identity, belief system, and values. At the core of these experiences is the complex emotion of awe that promotes learning, making it worthwhile to study from an educational point of view. Drawing studies may provide a useful measure of awe in children-one that is more intuitive and attractive than questionnaires alone.

Lingualyzer: A computational linguistic tool for multilingual and multidimensional text analysis.

Most natural language models and tools are restricted to one language, typically English. For researchers in the behavioral sciences investigating languages other than English, and for those researchers who would like to make cross-linguistic comparisons, hardly any computational linguistic tools exist, particularly none for those researchers who lack deep computational linguistic knowledge or programming skills. Yet, for interdisciplinary researchers in a variety of fields, ranging from psycholinguistics, social psychology, cognitive psychology, education, to literary studies, there certainly is a need for such a cross-linguistic tool.

[Endometriosis, you won't see it until you think of it].

For many people, including health care providers, endometriosis is an unknown disease. It can present in many different ways, making it difficult to diagnose. As a result the diagnosis is often missed and the right treatment cannot be started.

Surface and Contextual Linguistic Cues in Dialog Act Classification: A Cognitive Science View.

What role do linguistic cues on a surface and contextual level have in identifying the intention behind an utterance? Drawing on the wealth of studies and corpora from the computational task of dialog act classification, we studied this question from a cognitive science perspective. We first reviewed the role of linguistic cues in dialog act classification studies that evaluated model performance on three of the most commonly used English dialog act corpora. Findings show that frequency-based, machine learning, and deep learning methods all yield similar performance.

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases.

Lysosomal exoglycosidases are responsible for processing endocytosed glycans from the non-reducing end to produce the corresponding monosaccharides. Genetic mutations in a particular lysosomal glycosidase may result in accumulation of its particular substrate, which may cause diverse lysosomal storage disorders. The identification of effective therapeutic modalities to treat these diseases is a major yet poorly realised objective in biomedicine.

Connections between efficient control and spontaneous transitions in an Ising model.

A system can be driven between metastable configurations by a time-dependent driving protocol, which uses external control parameters to change the potential energy of the system. Here we investigate the correspondence between driving protocols that are designed to minimize work and the spontaneous transition paths of the system in the absence of driving. We study the spin-inversion reaction in a 2D Ising model, quantifying the timing of each spin flip and heat flow to the system during both a minimum-work protocol and a spontaneous transition.

Corneal reflections and skin contrast yield better memory of human and virtual faces.

Virtual faces have been found to be rated less human-like and remembered worse than photographic images of humans. What it is in virtual faces that yields reduced memory has so far remained unclear. The current study investigated face memory in the context of virtual agent faces and human faces, real and manipulated, considering two factors of predicted influence, i.

Aviation and neurophysiology: A systematic review.

This paper systematically reviews 20 years of publications (N = 54) on aviation and neurophysiology. The main goal is to provide an account of neurophysiological changes associated with flight training with the aim of identifying neurometrics indicative of pilot's flight training level and task relevant mental states, as well as to capture the current state-of-art of (neuro)ergonomic design and practice in flight training. We identified multiple candidate neurometrics of training progress and workload, such as frontal theta power, the EEG Engagement Index and the Cognitive Stability Index.

Zipf's law revisited: Spoken dialog, linguistic units, parameters, and the principle of least effort.

The ubiquitous inverse relationship between word frequency and word rank is commonly known as Zipf's law. The theoretical underpinning of this law states that the inverse relationship yields decreased effort in both the speaker and hearer, the so-called principle of least effort. Most research has focused on showing an inverse relationship only for written monolog, only for frequencies and ranks of one linguistic unit, generally word unigrams, with strong correlations of the power law to the observed frequency distributions, with limited to no attention to psychological mechanisms such as the principle of least effort.

Multidimensional minimum-work control of a 2D Ising model.

A system's configurational state can be manipulated using dynamic variation of control parameters, such as temperature, pressure, or magnetic field; for finite-duration driving, excess work is required above the equilibrium free-energy change. Minimum-work protocols in multidimensional control-parameter space have the potential to significantly reduce work relative to one-dimensional control. By numerically minimizing a linear-response approximation to the excess work, we design protocols in control-parameter spaces of a 2D Ising model that efficiently drive the system from the all-down to all-up configuration.

Information Thermodynamics of the Transition-Path Ensemble.

The reaction coordinate describing a transition between reactant and product is a fundamental concept in the theory of chemical reactions. Within transition-path theory, a quantitative definition of the reaction coordinate is found in the committor, which is the probability that a trajectory initiated from a given microstate first reaches the product before the reactant. Here we develop an information-theoretic origin for the committor and show how selecting transition paths from a long ergodic equilibrium trajectory induces entropy production which exactly equals the information that system dynamics provide about the reactivity of trajectories.

Steps minimize dissipation in rapidly driven stochastic systems.

Micro- and nanoscale systems driven by rapid changes in control parameters (control protocols) dissipate significant energy. In the fast-protocol limit, we find that protocols that minimize dissipation at fixed duration are universally given by a two-step process, jumping to and from a point that balances jump size with fast relaxation. Jump protocols could be exploited by molecular machines or thermodynamic computing to improve energetic efficiency, and implemented in nonequilibrium free-energy estimation to improve accuracy.

Cavity-BOX SOI: Advanced Silicon Substrate with Pre-Patterned BOX for Monolithic MEMS Fabrication.

Several Silicon on Insulator (SOI) wafer manufacturers are now offering products with customer-defined cavities etched in the handle wafer, which significantly simplifies the fabrication of MEMS devices such as pressure sensors. This paper presents a novel cavity buried oxide (BOX) SOI substrate (cavity-BOX) that contains a patterned BOX layer. The patterned BOX can form a buried microchannels network, or serve as a stop layer and a buried hard-etch mask, to accurately pattern the device layer while etching it from the backside of the wafer using the cleanroom microfabrication compatible tools and methods.

Measures of prefrontal functional near-infrared spectroscopy in visuomotor learning.

Functional near-infrared spectroscopy (fNIRS) is a promising technique for non-invasively assessing cortical brain activity during learning. This technique is safe, portable, and, compared to other imaging techniques, relatively robust to head motion, ocular and muscular artifacts and environmental noise. Moreover, the spatial resolution of fNIRS is superior to electroencephalography (EEG), a more commonly applied technique for measuring brain activity non-invasively during learning.

Electronic Continuous Pain Measurement vs Verbal Rating Scale in gynaecology: A prospective cohort study.

Objective: To compare pain measured with a new electronic device - the Continuous Pain Score Meter (CPSM) - and the Verbal Rating Scale (VRS) during gynaecological procedures in an outpatient setting, and to correlate these outcomes with baseline anxiety and patient (in)tolerance to the procedure.

Study Design: This prospective cohort study was undertaken in two centres: a university hospital and a large teaching hospital in The Netherlands. Patients undergoing an outpatient hysteroscopy, colposcopy or ovum pick-up procedure for in-vitro fertilization in one of the two participating hospitals with availability of the CPSM were included.

Creating Ambassadors of Planet Earth: The Overview Effect in K12 Education.

The overview effect is the commonly reported experience of astronauts viewing planet Earth from space and the subsequent reflection on and processing of this experience. The overview effect is associated with feelings of awe, self-transcendence, and a change of perspective and identity that manifest themselves in taking steps toward protecting the fragile ecosystem. In the current study, we investigated whether the overview effect can be obtained in school children when simulated using virtual reality (VR) and whether the effect has a positive impact on learning gains.

Non-invasive Neurophysiology in Learning and Training: Mechanisms and a SWOT Analysis.

Although many scholars deem non-invasive measures of neurophysiology to have promise in assessing learning, these measures are currently not widely applied, neither in educational settings nor in training. How can non-invasive neurophysiology provide insight into learning and how should research on this topic move forward to ensure valid applications? The current article addresses these questions by discussing the mechanisms underlying neurophysiological changes during learning followed by a SWOT (strengths, weaknesses, opportunities, and threats) analysis of non-invasive neurophysiology in learning and training. This type of analysis can provide a structured examination of factors relevant to the current state and future of a field.

Does Number Perception Cause Automatic Shifts of Spatial Attention? A Study of the Att-SNARC Effect in Numbers and Chinese Months.

The Attentional Spatial Numerical Association of Response Codes (Att-SNARC) effect has shown that number perception induces shifts in spatial attention (Fischer et al., 2003; Dodd et al., 2008).

Neurophysiological changes in visuomotor sequence learning provide insight in general learning processes: Measures of brain activity, skin conductance, heart rate and respiration.

Prior research has shown neurophysiological measures of learning yield large effect sizes, suggesting that these measures have high potential in providing insight into learning. Yet, most literature on learning and neurophysiological measures focused on a single outcome measure, neglecting the interplay between different types of measures. Additionally, it is not yet clear which measures change robustly in a way specific to the learning process.

Non-invasive neurophysiological measures of learning: A meta-analysis.

In a meta-analysis of 113 experiments we examined neurophysiological outcomes of learning, and the relationship between neurophysiological and behavioral outcomes of learning. Findings showed neurophysiology yielding large effect sizes, with the majority of studies examining electroencephalography and eye-related outcome measures. Effect sizes on neurophysiological outcomes were smaller than effect sizes on behavioral outcomes, however.