Publications by authors named "Lous J A E Doude van Troostwijk"
Article Synopsis
- - Volanesorsen is an RNA therapy that has shown effectiveness in reducing triglyceride (TG) levels in a 13-year-old girl with lipoprotein lipase (LPL) deficiency, a rare disorder that can lead to severe complications like pancreatitis.
- - The study observed that after starting weekly injections of Volanesorsen, TG levels dropped significantly, with no hospitalizations for pancreatitis in the first 14 months, unlike the patient's previous 21 admissions over a similar timeframe.
- - The treatment was well-tolerated, highlighting an improved quality of life for both the patient and her family, and suggesting the need for broader access to Volanesorsen for pediatric patients with LPL deficiency.
Clozapine is an effective atypical antipsychotic drug applied in the treatment of resistant schizophrenia. The drug is mainly metabolized by cytochrome P-450 (CYP) enzymes especially the isozyme CYP1A2. Remarkably, the effective dosage varies widely among patients, making it necessary to individualize drug therapy with clozapine.
View Article and Find Full Text PDFCytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Provocation with caffeine is used to estimate CYP1A2 activity, but in most tests a long period of caffeine abstinence has to be taken into account. We compared two novel methods with the currently applied test.
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