Publications by authors named "Lourdes Gallardo-Fuentes"
Article Synopsis
- Retinoic acid (RA) is crucial for various embryonic development processes, including body axis and central nervous system patterning, and its signaling influences gene expression through RA receptors.
- Treating zebrafish embryos with all-trans-RA (atRA) allows researchers to investigate how RA affects gene expression on a genome-wide scale using advanced sequencing techniques.
- The study reveals that RA signaling not only impacts specific gene targets but also alters chromatin structure and accessibility, thereby reorganizing chromatin architecture and influencing the regulation of key developmental genes.
Article Synopsis
- Skates, a type of cartilaginous fish, have unique wing-like pectoral fins that aid their survival in bottom-dwelling environments, but the genetic basis for this trait is not fully understood.
- Researchers analyzed the genome of the little skate species to uncover ancient vertebrate features and identified specific genomic changes that impact regulatory mechanisms involved in fin development.
- The study highlights the importance of genome restructuring and gene regulation in shaping skate fin morphology, emphasizing the role of the planar cell polarity pathway and a specific fin enhancer connected to hoxa gene expression.
The transcription factor p63 is an essential regulator of vertebrate ectoderm development, including epidermis, limbs, and craniofacial tissues. Here, we have investigated the evolutionary conservation of p63 binding sites (BSs) between zebrafish and human. First, we have analyzed sequence conservation of p63 BSs by comparing ChIP-seq data from human keratinocytes and zebrafish embryos, observing a very poor conservation.
View Article and Find Full Text PDFThe transcription factor p63 is a master regulator of ectoderm development. Although previous studies show that p63 triggers epidermal differentiation in vitro, the roles of p63 in developing embryos remain poorly understood. Here, we use zebrafish embryos to analyze in vivo how p63 regulates gene expression during development.
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