Publications by authors named "Louison Collet"
Article Synopsis
- The differentiation of megakaryocytes (Mks) from haematopoietic stem cells is influenced by mechanical forces, with PIEZO1 playing a key role in sensing these forces.
- Gain-of-function mutations in PIEZO1 lead to hereditary xerocytosis, highlighting its importance in thrombosis and potentially affecting platelet formation.
- This study demonstrated that activating PIEZO1 with YODA1 initially reduces Mk maturation but later promotes endomitosis and proplatelet formation, indicating a complex regulatory role for PIEZO1 in Mk development.
Article Synopsis
- The BK polyomavirus (BKPyV) typically causes no symptoms in healthy adults but can lead to serious health issues like nephropathies and hemorrhagic cystitis in immunocompromised patients, particularly those with organ transplants.
- Recent research shows that BKPyV can use extracellular vesicles to move between cells without causing cell damage, which is a unique strategy for virus entry and exit.
- The study looked into whether BKPyV uses certain viral protein domains to assist in this vesicle trafficking, finding that while a specific domain in the VP1 protein doesn't aid in vesicle association, it's critical for proper viral particle assembly.
Introduction: Leukemogenesis is a complex process that interconnects tumoral cells with their microenvironment, but the effect of mechanosensing in acute myeloid leukemia (AML) blasts is poorly known. PIEZO1 perceives and transmits the constraints of the environment to human cells by acting as a non-selective calcium channel, but very little is known about its role in leukemogenesis.
Results: For the first time, we show that PIEZO1 is preferentially expressed in healthy hematopoietic stem and progenitor cells in human hematopoiesis, and globally overexpressed in AML cells.
Article Synopsis
- Scientists found that STIM2 is a protein that helps control how certain blood cells, called monocytic cells, grow and survive in a type of cancer called acute myeloid leukemia (AML).
- When they studied 407 AML patients, they discovered that more STIM2 meant shorter survival, which is not good.
- By lowering STIM2 levels in cancer cells, the scientists saw that the cells stopped growing and started breaking down, showing how STIM2 is important for keeping cells healthy and stable.
Background: Acquired resistance to sorafenib in hepatocellular carcinoma (HCC) patients results in poor prognosis. Epithelial-to-mesenchymal transition (EMT) is the major mechanism implicated in the resistance to sorafenib. We have reported the tumor suppressor role of SLAMF3 (signaling lymphocytic activation molecules family 3) in HCC progression and highlighted its implication in controlling the MRP-1 transporter activity.
View Article and Find Full Text PDFBone tissue engineering goes beyond the limitations of conventional methods of treating bone loss, such as autograft-induced morbidity and a lack of integration for large grafts. Novel biomimicry approaches (using three-dimensional [3D] electrospinning and printing techniques) have been designed to offer the most appropriate environment for cells and thus promote bone regeneration. In the present study, we assessed the bone regeneration properties of a composite 3D honeycomb structure from the electrostatic template-assisted deposition process by an alternate deposition of electrospun polycaprolactone (PCL) nanofibers and electrosprayed hydroxyapatite nanoparticles (nHA) on a honeycomb micropatterned substrate.
View Article and Find Full Text PDFIn bone tissue engineering, autologous cells are combined with osteoconductive scaffolds and implanted into bone defects. The major challenge is the lack of post-implantation vascular growth into biomaterial. The objective of the present study was to develop a new alginate-based hydrogel that enhances the regeneration of bone defects after surgery.
View Article and Find Full Text PDFBackground: Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kinase inhibitors (TKIs) in lung cancer have not yet been reported in GBM.
Case Presentation: Using next-generation sequencing, array comparative genomic hybridization and droplet digital PCR, we identified the p.