Publications by authors named "Louise Roche"
Article Synopsis
- - Leptospirosis is a severe disease caused by bacteria, and the authors investigated the immune responses in resistant mice versus susceptible hamsters during early infection.
- - They found that the immune response, specifically the ratio of anti-inflammatory cytokine IL-10 to pro-inflammatory cytokines TNF-α and IL-1β, was higher in mice than in hamsters, indicating that the host's immune response plays a significant role in survival and disease expression.
- - Additionally, using a technique to neutralize IL-10 in infected mice revealed that this cytokine may affect how well the host clears the bacteria and regulates other immune responses.
Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira. Humans can be infected after exposure to contaminated urine of reservoir animals, usually rodents, regarded as typical asymptomatic carriers of leptospires. In contrast, accidental hosts may present an acute form of leptospirosis with a range of clinical symptoms including the development of Acute Kidney Injury (AKI).
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- - Leptospirosis is a disease caused by the bacteria Leptospira, and this study focuses on a strain (B3-13S) from a wild mouse in New Caledonia identified as part of the L. borgpetersenii Ballum serogroup.
- - When hamsters were infected with the bacteria, they exhibited severe organ damage and tissue lesions similar to those seen with other strains of Leptospira.
- - The findings suggest that the B3-13S strain can help develop models for studying both severe acute and chronic forms of leptospirosis, which is important as this serogroup is increasingly reported in human cases.