Introducing a novel sub-millimeter lung CT image registration error quantitation tool.

Background: Lung computed tomography (CT) scan image registration is being used for lung function analysis such as ventilation. Given the high sensitivity of functional analyses to image registration errors, an image registration error scoring tool that can measure submillimeter image registration errors is needed.

Purpose: To propose an image registration error scoring tool, termed λ, whose spatial sensitivity can be used to quantify image registration errors in steep image gradient regions under realistic noise conditions.

Motion compensated cone-beam CT reconstruction using anmotion model from CT simulation: a pilot study.

. To combat the motion artifacts present in traditional 4D-CBCT reconstruction, an iterative technique known as the motion-compensated simultaneous algebraic reconstruction technique (MC-SART) was previously developed. MC-SART employs a 4D-CBCT reconstruction to obtain an initial model, which suffers from a lack of sufficient projections in each bin.

An analysis of the regional heterogeneity in tissue elasticity in lung cancer patients with COPD.

Purpose: Recent advancements in obtaining image-based biomarkers from CT images have enabled lung function characterization, which could aid in lung interventional planning. However, the regional heterogeneity in these biomarkers has not been well documented, yet it is critical to several procedures for lung cancer and COPD. The purpose of this paper is to analyze the interlobar and intralobar heterogeneity of tissue elasticity and study their relationship with COPD severity.

Ventilation measurements using fast-helical free-breathing computed tomography.

Purpose: To examine the use of multiple fast-helical free breathing computed tomography (FHFBCT) scans for ventilation measurement.

Methods: Ten patients were scanned 25 times in alternating directions using a FHFBCT protocol. Simultaneously, an abdominal pneumatic bellows was used as a real-time breathing surrogate.

3D printing for rapid prototyping of low-Z/density ionization chamber arrays.

Purpose: To explore 3D printing for rapid development of prototype thin slab low-Z/density ionization chamber arrays viable for custom needs in radiotherapy dosimetry and quality assurance (QA).

Materials And Methods: We designed and fabricated parallel plate ionization chambers and ionization chamber arrays using an off-the-shelf 3D printing equipment. Conductive components of the detectors were made of conductive polylactic acid (cPLA) and insulating components were made of acrylonitrile butadiene styrene (ABS).