Deficiency of T-type Ca channels Ca3.1 and Ca3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.

T-type Ca channel Ca3.1 promotes microvessel contraction ex vivo. It was hypothesized that in vivo, functional deletion of Ca3.

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.

Aim: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin.

Methods: We performed an open-label, randomized, two-phase, five-drug clinical pharmacokinetic cocktail crossover study in 12 healthy men with and without pretreatment with 1 g dicloxacillin three times daily for 10 days. Plasma and urine were collected over 24 h and the concentration of all five drugs and their primary metabolites was determined using a liquid chromatography coupled to triple quadrupole mass spectrometry method.