Publications by authors named "Louise I Pease"
The DNA repair enzyme, aprataxin, plays a role in innate immune signaling.
Front Aging Neurosci
December 2023
Article Synopsis
- - Ataxia with oculomotor apraxia type 1 (AOA1) is a neurodegenerative disorder that leads to coordination issues in movement, speech, and eye tracking, caused by mutations in the APTX gene which is important for DNA repair.
- - APTX deficiency results in mitochondrial dysfunction and increased DNA damage, which may activate immune responses, leading to inflammation due to misplacement of DNA in the cells.
- - The study found that APTX knockout in microglial cells affects their immune response, with downregulation of key pathways related to DNA and RNA sensing, suggesting the need for further research into potential treatments for AOA1.
The development of tendinopathy is influenced by a variety of factors including age, gender, sex hormones and diabetes status. Cross platform comparative analysis of transcriptomic data elucidated the connections between these entities in the context of ageing. Tissue-engineered tendons differentiated from bone marrow derived mesenchymal stem cells from young (20-24 years) and old (54-70 years) donors were assayed using ribonucleic acid sequencing (RNA-seq).
View Article and Find Full Text PDF