Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome.

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant or spontaneous disorder characterized by multiple cutaneous basal cell carcinomas, odontogenic keratocysts, skeletal anomalies and facial dysmorphology, including cleft lip and palate. Causative mutations for NBCCS occur in the PTCH1 gene on chromosome 9q22.3-q31, which encodes the principle receptor for the Hedgehog signalling pathway.

The effect of different exposure routines on the surface microhardness of a light-activated resin composite.

Objectives: To compare the surface microhardness of a resin composite following exposure to a pulse-delayed activation routine and a standard continuous routine using a quartz-halogen lamp. Additionally, to assess the effect of increasing the distance between the activator light and the specimen using a continuous exposure routine.

Method And Materials: Disk specimens of a commercial resin composite restorative material were exposed to a quartz-halogen lamp in a three-step pulse-delayed routine.

Callers' ability to understand advice received from a telephone health-line service: comparison of self-reported and registered data.

Objective: To validate users' perception of nurses' recommendations to look for another health resource among clients seeking teleadvice. To analyze the effects of different users' and call characteristics on the incorrectness of the self-report.

Data Sources/study Setting: This study is a secondary analysis of data obtained from 4,696 randomly selected participants in a survey conducted in 1997 among users of Info-Santé CLSC, a no-charge telenursing health-line service (THLS) available all over the province of Québec.

[Recommendations for appeal to another resource in a health case brought by nurses in the Info-Health Service CLSC: convergence between utilization declarations and informants' data].

Objectives: To examine the perception of telephone advice-line users as to whether or not a formal recommendation had been made to seek another consultation and to compare users' perception to what the nurse documented. To analyze the effects of different users' and call characteristics on the incorrectness of the self-report.

Data Sources/study Setting: This study is a secondary analysis of data obtained from 4,696 randomly selected participants in a survey conducted among users of Info-Santé CLSC, a free-of-charge telenursing health-line service (THLS) available throughout the province of Quebec.