Publications by authors named "Louise C Enfield"
Diffuse optical imaging and spectroscopy use near-infrared light to derive physiological parameters such as total hemoglobin concentration and tissue oxygen saturation. Numerous clinical studies have been carried out, either using stand-alone optical methods or in combination with alternative imaging techniques. Studies have demonstrated that diffuse optical imaging and spectroscopy are able to distinguish malignant lesions from benign tissues.
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- Optical tomography is being refined to detect diseases in the adult female breast using a specialized 32-channel imaging system.
- The imaging setup involves patients placing their breasts in a hemispherical cup filled with a scattering fluid, allowing for better visualization of tumors.
- Out of 38 patients scanned, tumor-related hypervascularization showed high contrast in images, but only half of the benign fibroadenomas were detectable, with most indicating changes in blood volume and oxygen levels.
Screening X-ray mammography is limited by false positives and negatives leading to unnecessary physical and psychological morbidity. Diffuse Optical Imaging using harmless near infra red light, provides lesion detection based on functional abnormalities and represents a novel diagnostic arm that could complement traditional mammography. Reviews of optical breast imaging have not been systematic, are focused mainly on technological developments, and have become superseded by rapid technological advancement.
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