The potential of reuterin derived from Indonesian strain of against endodontic pathogen biofilms in vitro and ex vivo.

Objectives: Despite the use of common irrigating solution with antimicrobial properties, failed root canal treatment remains a significant problem in endodontics. In the present study, we examined the efficacy of reuterin derived from probiotic bacteria, on the biofilms of major endodontic pathogens using ex vivo model of root canal infections.

Methods: Biofilms of major endodontic pathogens namely , , and were formed on root canals of 60 human premolar tooth samples accordingly a standard protocol.