Evidence cornered: Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT trial).

Clinical Question: Does intravenous iron given to anaemic patients (haemoglobin [Hb] <130 g/L for men and 120 g/L for women) before major elective open abdominal surgery reduce the need for blood transfusions or death within 30 days of surgery?

Evidence From Trial: There were no significant differences in the rates of blood transfusion or death at 30 days after the index operation between anaemic patients who received intravenous iron preoperatively and those who did not.

Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study.

Background: Optimal prophylactic and therapeutic management of thromboembolic disease in patients with COVID-19 remains a major challenge for clinicians. The aim of this study was to define the incidence of thrombotic and haemorrhagic complications in critically ill patients with COVID-19. In addition, we sought to characterise coagulation profiles using thromboelastography and explore possible biological differences between patients with and without thrombotic complications.