Anti-DFS70 antibodies are associated with atopic dermatitis and can cause misdiagnosis of connective tissue disease.

Background And Objectives: Antinuclear antibodies (ANA) detected by HEp2 cell immunofluorescence staining are a characteristic finding in patients with connective tissue disease (CTD). However, even detection of highly elevated ANA is not conclusive for CTD and can result in misdiagnosis. Anti-DFS70 antibodies are ANA, which may also be highly elevated in people without CTD.