Publications by authors named "Louis-Victorien Vieillard"
Article Synopsis
- Tumor-infiltrating memory T cell subpopulations in non-small cell lung cancer (NSCLC) can be categorized based on various surface markers, with CD103 often used but not universally expressed.
- In studies, multiparametric cytometry and multiplex immunofluorescence techniques were applied to analyze T-cell behavior in vaccinated mice and human NSCLC patients, revealing distinct subpopulations and their impact on clinical outcomes.
- Results showed that a specific double-positive T cell subset (CD103+CD49a+) was more functional than a single-positive subset (CD49a+), with implications for predicting responses to immunotherapy, particularly relating to PD-1 treatment.
Importance: There is still considerable controversy in the literature regarding the capacity of intramuscular messenger RNA (mRNA) vaccination to induce a mucosal immune response.
Objective: To compare serum and salivary IgG and IgA levels among mRNA-vaccinated individuals with or without previous SARS-CoV-2 infection.
Design, Setting, And Participants: In this cohort study, SARS-CoV-2-naive participants and those with previous infection were consecutively included in the CoviCompare P and CoviCompare M mRNA vaccination trials and followed up to day 180 after vaccination with either the BNT162b2 (Pfizer-BioNTech) vaccine or the mRNA-1273 (Moderna) vaccine at the beginning of the COVID-19 vaccination campaign (from February 19 to June 8, 2021) in France.
Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.
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