Publications by authors named "Louis-Olivier Roy"
Background: The quantitative effects of congenital heart disease (CHD) risk factors are not fully understood. We conducted a meta-analysis of all CHD risk factors. This report explores maternal medication, assisted reproductive technologies (ART), and familial and fetal factors.
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- The study focused on children under 18 with tetralogy of Fallot and the effects of pulmonary valve replacement (PVR), particularly its timing and impact on health outcomes.
- Researchers analyzed data from 316 patients born in Québec from 1982 to 2015, looking at hospitalization rates, interventions, and mortality rates comparing those who received PVR to those who did not.
- Results indicated that while patients who had PVR experienced higher rates of cardiac hospitalizations, their overall health outcomes regarding all-cause hospitalizations, cardiac procedures, and mortality were similar to those without PVR.
Article Synopsis
- A national registry for congenital heart disease (CHD) in Canada aims to streamline research, cut costs, and enhance statistical power by automatically identifying CHD patients from existing clinical data.
- This project successfully extracted data from 885,287 echocardiogram reports and 70,121 clinical records, identifying over 43,000 children and nearly 5,000 fetuses with CHD.
- The initial registry in Québec demonstrates the potential for a centralized, user-friendly database that can support various CHD research projects and potentially expand to a national level.
Article Synopsis
- - The study analyzed long-term follow-up data from 904 patients with tetralogy of Fallot in Québec, revealing that about 50.3% experienced loss to follow-up (LTFU) over 30 years, but many returned to care, with 70.6% still actively monitored after three decades.
- - Key factors that reduced the risk of LTFU included surgical repairs using conduits and transannular patches, both of which significantly decreased the likelihood of patients falling out of care.
- - Interestingly, while LTFU patients had fewer cardiac hospitalizations and interventions, their rates of cardiac mortality were similar to those who continued follow-up, suggesting that not attending regular care did not significantly impact overall survival.
Incremental Detection of Severe Congenital Heart Disease by Fetal Echocardiography Following a Normal Second Trimester Ultrasound Scan in Québec, Canada.
Circ Cardiovasc Imaging
April 2022
Background: The benefit of fetal echocardiograms (FE) to detect severe congenital heart diseases (SCHD) in the setting of a normal second-trimester ultrasound is unclear. We aimed to assess whether the increase in SCHD detection rates when FE are performed for risk factors in the setting of a normal ultrasound was clinically significant to justify the resources needed.
Methods: This is a multicenter, population-based, retrospective cohort study, including all singleton pregnancies and offspring in Quebec (Canada) between 2007 and 2015.