Publications by authors named "Louis Schubert"
Article Synopsis
- Thyroid cancer is the most common type of endocrine cancer and generally has a good outlook, but some cases, particularly follicular-origin cancers, can become aggressive and resistant to treatment.
- A significant number of these cancers show hyper-activation of the MAPK signaling pathway due to specific mutations, which has led to the testing of targeted therapies, such as BRAF and MEK inhibitors.
- Current strategies include using these inhibitors to try and redifferentiate refractory tumors, potentially allowing for subsequent treatment with radioactive iodine, but resistance to treatment remains a challenge.
Background: Sudden cardiac deaths are twice more frequent in diabetic patients with cardiac autonomic neuropathy. Sudden cardiac death etiologies remain unclear and no recommendations are made to identify factors associated with cardiorespiratory arrest in diabetic patients. We hypothesized, from two clinical cases, that impaired hypoxic ventilatory drive, induced by diabetic autonomic neuropathy, is a cause of misdiagnosed severe cardiac events.
View Article and Find Full Text PDFAmiodarone-induced thyrotoxicosis (AIT) are not uncommon endocrinopathies. Clinicians are sometimes faced with difficult diagnostic and therapeutic situations. The disease pathophysiology is partially understood, explaining the lack of predictive factors for occurrence.
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