Evolutionary trajectories of β-lactam resistance in strains.

Unlabelled: Resistance to ampicillin and imipenem in is infrequent. However, the evolution of resistance can occur through prolonged antibiotic exposure during the treatment of chronic infections. In this study, we conducted a long-term evolution experiment using four genetically diverse strains of with varying susceptibilities to ampicillin and imipenem.

Evolutionary trajectories of β-lactam resistance in strains.

Unlabelled: Resistance to ampicillin and imipenem in is infrequent. However, the evolution of resistance can occur through prolonged antibiotic exposure during the treatment of chronic infections. In this study, we conducted a Long-Term Evolution Experiment (LTEE) using four genetically diverse strains of with varying susceptibilities to ampicillin and imipenem.

Medical Crowdfunding in India: The Need for a Strong Legal Enforcement System.

In India, poor health insurance coverage and high out-of-pocket expenditure especially for chronic and rare genetic/life-threatening diseases is a reality. People who use medical crowdfunding as an option to meet medical expenditures and the sudden growth of new fundraising platforms are significant developments in healthcare. The digital platforms in fundraising and the multitude of transactions they perform are increasing in the country and have a significant impact on the health sector and the rights of the patients which points toward the need for more effective regulation.

Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5.

Penicillin-binding proteins (PBPs) are essential for the formation of the bacterial cell wall. They are also the targets of β-lactam antibiotics. In Enterococcus faecium, high levels of resistance to β-lactams are associated with the expression of PBP5, with higher levels of resistance associated with distinct PBP5 variants.

Penicillin-Binding Proteins and Alternative Dual-Beta-Lactam Combinations for Serious Enterococcus faecalis Infections with Elevated Penicillin MICs.

Ampicillin-ceftriaxone has become a first-line therapy for Enterococcus faecalis endocarditis. We characterized the penicillin-binding protein (PBP) profiles of various E. faecalis strains and tested for synergy to better inform beta-lactam options for the treatment of E.

Meropenem plus Ceftaroline Is Active against Enterococcus faecalis in an Pharmacodynamic Model Using Humanized Dosing Simulations.

The standard of care for serious Enterococcus faecalis infections is ampicillin plus ceftriaxone. Ampicillin's inconvenient dosing schedule, drug instability, allergy potential, along with ceftriaxone's high risk for Clostridioides difficile infection and its promotion of vancomycin-resistant enterococci (VRE), led our team to explore alternative options. This work aimed to understand the role of carbapenems in combination with cephalosporins in these infections.

Houston, We Have a Problem: Reports of Clostridioides difficile Isolates With Reduced Vancomycin Susceptibility.

During the past 4 decades, oral vancomycin has been a mainstay of Clostridioides difficile infection (CDI) therapy with no reports of treatment failure due to emergence of vancomycin resistance. However, C. difficile isolates with high-level phenotypic resistance to vancomycin have recently been reported in 3 distinct geographic regions.

Health, Economic and Social Development Challenges of the COVID-19 Pandemic: Strategies for Multiple and Interconnected Issues.

The COVID-19-pandemic-related economic and social crises are leading to huge challenges for all spheres of human life across the globe. Various challenges highlighted by this pandemic include, but are not limited to, the need for global health cooperation and security, better crisis management, coordinated funding in public health emergencies, and access to measures related to prevention, treatment and control. This systematic review explores health, economic and social development issues in a COVID-19 pandemic context and aftermath.

The Great Lockdown in the Wake of COVID-19 and Its Implications: Lessons for Low and Middle-Income Countries.

Concern for public health has been growing with the increasing volume of cases of COVID-19 in India. To combat this pandemic, India has implemented nationwide lockdowns, and unlocking phases continue with certain restrictions in different parts of the country. The lockdown has required people to adopt social-distance measures to minimize contacts in order to reduce the risks of additional infection.

Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter.

differs from many other common human pathogens in its physiology and in its susceptibility to antimicrobial agents. Multiresistant strains owe their phenotypes to a combination of intrinsic and acquired antimicrobial resistance determinants. Acquired resistance is due to frequenting multicultural environments, its capacity to mate with different species, and the nullification of its own defense mechanisms in some lineages.

Assessment of groundwater vulnerability using integrated remote sensing and GIS techniques for the West Bengal coast, India.

Groundwater in the coastal districts of West Bengal, India is highly susceptible to various factors such as over-pumping, variations in rainfall, lower elevation and risk due to sea level rise. In addition to these factors, tropical cyclone induced storm surge and saltwater intrusion also induce potential risks to the quality of the coastal aquifers. There are several knowledge gaps, as many of these factors have not previously been systematically and rigorously analysed; furthermore, up-to-date information is either unavailable or insufficient.

An Updated History of : 2000-2020.

Since its inaugural issue nearly half a century ago, has served as a premier source for reports on scientific and clinical advances in the field of antimicrobial chemotherapy. As a follow-up to the previous "History of from 1972 to 1998" written by George A. Jacoby (Antimicrob Agents Chemother 43:999-1002, 1999, https://doi.

Resistance in Vancomycin-Resistant Enterococci.

Serious infections owing to vancomycin-resistant enterococci have historically proven to be difficult clinical cases, requiring combination therapy and management of treatment-related toxicity. Despite the introduction of new antibiotics with activity against vancomycin-resistant enterococci to the therapeutic armamentarium, significant challenges remain. An understanding of the factors driving the emergence of resistance in vancomycin-resistant enterococci, the dynamics of gastrointestinal colonization and microbiota-mediated colonization resistance, and the mechanisms of resistance to the currently available therapeutics will permit clinicians to be better prepared to tackle these challenging hospital-associated pathogens.

Indicators of Healthy Architecture-a Systematic Literature Review.

The design of the built environment plays an important role as a determinant of health. As a society, we are spending an increasing proportion of our time indoors and now spend over 80% of our life inside, so the design of buildings can greatly impact on human health. Accordingly, architecture health indices (AHIs) are used to evidence the effects on human health associated with the design of buildings.

Fosfomycin for Injection (ZTI-01) Versus Piperacillin-tazobactam for the Treatment of Complicated Urinary Tract Infection Including Acute Pyelonephritis: ZEUS, A Phase 2/3 Randomized Trial.

Background: ZTI-01 (fosfomycin for injection) is an epoxide antibiotic with a differentiated mechanism of action (MOA) inhibiting an early step in bacterial cell wall synthesis. ZTI-01 has broad in vitro spectrum of activity, including multidrug-resistant Gram-negative pathogens, and is being developed for treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) in the United States.

Methods: Hospitalized adults with suspected or microbiologically confirmed cUTI/AP were randomized 1:1 to 6 g ZTI-01 q8h or 4.

The Enterococcus: a Model of Adaptability to Its Environment.

The genus comprises a ubiquitous group of Gram-positive bacteria that are of great relevance to human health for their role as major causative agents of health care-associated infections. The enterococci are resilient and versatile species able to survive under harsh conditions, making them well adapted to the health care environment. Two species cause the majority of enterococcal infections: and Both species demonstrate intrinsic resistance to common antibiotics, such as virtually all cephalosporins, aminoglycosides, clindamycin, and trimethoprim-sulfamethoxazole.

Updating the determinants of health model in the Information Age.

In 1991, Dahlgren and Whitehead produced a highly influential model of the determinants of health that has since been used by numerous national and international public health organizations globally. The purpose of the model is to enable interventions that improve health to be addressed at four key policy levels. It is not a model of health or disease; instead the model is structured around health policy decision-making.

Antimicrobial Stewardship and Antimicrobial Resistance.

Antimicrobial stewardship programs aim to reduce costs, optimize therapeutic outcomes, and reduce antimicrobial resistance. Reductions of antimicrobial resistance are the most elusive because emergence and spread of resistant bacteria involves antimicrobial selective pressure and lapses in infection control techniques. The relationship between antimicrobial usage and resistance is not always direct.