The use of hydrogen peroxide for achieving dermal hemostasis after burn excision in a patient with platelet dysfunction.

As a topical hemostatic agent, hydrogen peroxide (3%) has been applied to tangential excisions of burn patients. Hydrogen peroxide provides an adjunct to topical epinephrine for hemostasis and clinically has been most useful in patients with known platelet dysfunction. Hydrogen peroxide should be irrigated from the wound bed before the placement of skin grafting because of its potential to inhibit wound healing.

In vivo use of human fibrin glue under the subperiosteal and subcutaneous planes in Holtzman rats.

Background: Commercial fibrin sealant has been increasingly used off-label in the United States for aesthetic surgical procedures to minimize postoperative drainage, hematoma and seroma collections, ecchymosis, and edema.

Objective: We sought to determine the optimal concentrations of thrombin and fibrinogen to extend the sealant adhesion time and to maintain the maximal glue strength, respectively, in subperiosteal and subcutaneous planes in Holtzman rats.

Methods: Three preparations of 2-component fibrin sealant from the Hemaseel APR kit (Haemacure Corp.

Necrotizing fasciitis: a fourteen-year retrospective study of 163 consecutive patients.

This review was prompted by continued public and professional interest of necrotizing fasciitis as well as worldwide increases in the incidence of streptococcal invasive infections. Our objective was to outline the clinical course of necrotizing fasciitis and delineate factors relating to mortality among 163 diagnosed patients. Over 14 years patients diagnosed with necrotizing fasciitis were reviewed for patient history, comorbid conditions, and progression of clinical course.