Real-world use of cenobamate in adults: Efficacy and predictors of treatment response.

Objective: This study assesses the efficacy, safety, and tolerability of cenobamate using long-term real-world data, incorporating both seizure reduction and seizure-freedom periods, and examines baseline clinical variables to determine predictors of response.

Methods: We retrospectively analyzed all patients prescribed cenobamate from May 2020 to July 2021. The primary outcome was 12-month seizure frequency reduction for each seizure type, stratified by baseline seizure frequency (higher vs lower frequency: ≥2 seizures vs <2 seizures in the preceding 3 months).