Publications by authors named "Louis Nygaard"
Introduction: We tested the feasibility of adding a potassium binder to enable increased renin angiotensin aldosterone system inhibition (RAASi) and reduce albuminuria in patients with chronic kidney disease (CKD). In a controlled trial design, a potassium binder was introduced exclusively in patients developing hyperkalemia after intensified RAASi, thereby mirroring clinical decision-making.
Methods: We planned to include 140 patients aged 18 to 80 years with estimated glomerular filtration rate (eGFR) 25 to 60 ml/min per 1.
Article Synopsis
- This study examined cardiovascular screening in patients with ANCA-associated vasculitis (AAV) and found higher rates of ECG abnormalities compared to matched controls.
- A total of 1431 AAV patients were analyzed, revealing a significant link between major ECG abnormalities and increased cardiovascular mortality risk.
- The findings suggest incorporating ECG assessments into regular care for AAV patients to better manage their cardiovascular health.
Article Synopsis
- A study was conducted to determine if patients with ANCA-associated vasculitis (AAV) are at a higher risk for cardiovascular disease before being diagnosed with AAV.
- Researchers used data from Danish registries, matching 2371 AAV patients with 7113 controls, and analyzed various cardiovascular outcomes over different timeframes leading up to the diagnosis.
- The findings revealed that AAV patients experienced significantly higher rates of cardiovascular issues, especially within a month prior to diagnosis, highlighting the need for clinicians to monitor cardiovascular health early in these patients.
Objectives: To examine long-term cardiovascular outcomes and temporal trends among patients with ANCA-associated vasculitis (AAV) using Danish nationwide registries.
Methods: Using a cohort design, we examined patients with granulomatosis with polyangiitis (ICD-10: DM31.3) and microscopic polyangiitis (ICD-10: DM3.
Article Synopsis
- Intestinal insufficiency and intestinal failure often lead to malabsorption of nutrients, increasing the risk of malnutrition and sarcopenia (loss of muscle mass and function).
- A study of 113 outpatients found that 53.1% had sarcopenia, with a higher prevalence in those with intestinal failure (72.7%) compared to those with intestinal insufficiency (34.5%).
- Key risk factors for sarcopenia included excessive alcohol use, having intestinal failure, and inflammatory activity, with a trend suggesting hypermetabolism as a potential risk as well.
Background & Aims: Intestinal insufficiency and intestinal failure are associated with malabsorption of micro- and macronutrients that may negatively influence bone metabolism and increase the risk for developing osteoporosis. However, information regarding prevalence and contribution of individual risk factors is scarce. We investigated the prevalence of osteoporosis in patients with intestinal insufficiency and intestinal failure and identified associated risk factors.
View Article and Find Full Text PDFCan We Rely on Predicted Basal Metabolic Rate in Patients With Intestinal Failure on Home Parenteral Nutrition?
JPEN J Parenter Enteral Nutr
September 2017
Background And Aims: Intestinal failure (IF) is a serious and common complication of short bowel syndrome with patients depending on parenteral nutrition (PN) support. Effective nutrition management requires an accurate estimation of the patient's basal metabolic rate (BMR) to avoid underfeeding or overfeeding. However, indirect calorimetry, considered the gold standard for BMR assessment, is a time- and resource-consuming procedure.
View Article and Find Full Text PDFBackground & Aim: Patients with intestinal failure (IF) are dependent on parenteral nutrition delivered through central access such as Hickman™ catheters. The peripherally inserted central catheter (PICC) is becoming increasingly popular for the purpose. The aim of the present study was to compare complication rates between the two types of catheters.
View Article and Find Full Text PDFBackground: Tunneled, cuffed, central venous catheters, including Hickman catheters and peripherally inserted central venous catheters (PICCs), are the most commonly used venous access for home parenteral nutrition (HPN) therapy. Catheter-related bloodstream infection is the most prevalent and severe complication. This study investigated whether environmental risk factors, including smoking, catheter management by a home care nurse, colectomy with stoma, number of infusion days per week, and C-reactive protein at catheter insertion day, influenced the time to first catheter-related bloodstream infection (CRBSI).
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