CRISPR in 3D: Innovations in Disease Modelling and Personalized Medicine.

The CRISPR-Cas system of genetic engineering has had a significant impact on science and society since its advent in 2013. CRISPR integration with 3D culture systems such as organ-on-a-chips, as well as fast emerging commercial technologies, has encouraged translation of more complex pathophysiological modelling and personalized medicine.[Formula: see text].

Microbial forensics: what we've learned from Amerithrax and beyond.

The Amerithrax investigation into anthrax letter attacks in the USA forever changed the game in microbial forensics. Here we review the techniques used, then and now, to neutralize bioterrorism threats. [Formula: see text].

Nanotechnology and cancer therapeutics: delivering on the hype?

Nanoparticle drug delivery systems are a promising development in cancer therapy for reducing toxicity and drug resistance, whilst improving precision targeting. Several types of nanotechnology are in development, with some receiving market approval and others proving difficult to translate to the bedside. [Formula: see text].

Reproducibility in the lab: the proof is in the protocol.

The replication crisis has gained traction in the scientific community over the past decade. Basic researchers have shown the reproducibility of key data from the lab is low and there is a clear need to improve lab protocol and technique.