The long and sinuous road to phage-based therapy of infections.

With the antibiotic crisis and the rise in antimicrobial resistance worldwide, new therapeutic alternatives are urgently needed. Phage therapy represents one of the most promising alternatives but for some pathogens, such as , important challenges are being faced. The perspective of phage therapy to treat infections is complicated by the fact that no strictly lytic phages have been identified so far, and current temperate phages generally have a narrow host range.

Arctic mid-winter phytoplankton growth revealed by autonomous profilers.

It is widely believed that during winter and spring, Arctic marine phytoplankton cannot grow until sea ice and snow cover start melting and transmit sufficient irradiance, but there is little observational evidence for that paradigm. To explore the life of phytoplankton during and after the polar night, we used robotic ice-avoiding profiling floats to measure ocean optics and phytoplankton characteristics continuously through two annual cycles in Baffin Bay, an Arctic sea that is covered by ice for 7 months a year. We demonstrate that net phytoplankton growth occurred even under 100% ice cover as early as February and that it resulted at least partly from photosynthesis.

The importance of for the feeding success of young polar cod: a circumpolar synthesis.

Understanding the feeding ecology of polar cod () during its first year of life is crucial to forecasting its response to the ongoing borealization of Arctic seas. We investigated the relationships between diet composition and feeding success in 1797 polar cod larvae and juveniles 4.5-55.

Efficacy and safety of remifentanil in a rapid sequence induction in elderly patients: A three-arm parallel, double blind, randomised controlled trial.

Background: Rapid sequence induction (RSI) is recommended in patients at risk of aspiration, but induced haemodynamic adverse events, including tachycardia. In elderly patients, this trial aimed to assess the impact of the addition of remifentanil during RSI on the occurrence of: tachycardia (primary outcome), hypertension (due to intubation) nor hypotension (remifentanil).

Methods: In this three-arm parallel, double blind, multicentre controlled study, elderly patients (65 to 90 years old) hospitalised in three centres and requiring RSI were randomly allocated to three groups, where anaesthesia was induced with etomidate (0.

Pan-Arctic concentrations of mercury and stable isotope ratios of carbon (δ(13)C) and nitrogen (δ(15)N) in marine zooplankton.

Zooplankton play a central role in marine food webs, dictating the quantity and quality of energy available to upper trophic levels. They act as "keystone" species in transfer of mercury (Hg) up through the marine food chain. Here, we present the first Pan-Arctic overview of total and monomethylmercury concentrations (THg and MMHg) and stable isotope ratios of carbon (δ(13)C) and nitrogen (δ(15)N) in selected zooplankton species by assembling data collected between 1998 and 2012 from six arctic regions (Laptev Sea, Chukchi Sea, southeastern Beaufort Sea, Canadian Arctic Archipelago, Hudson Bay and northern Baffin Bay).

Arctic underwater noise transients from sea ice deformation: Characteristics, annual time series, and forcing in Beaufort Sea.

A 13-month time series of Arctic Ocean noise from the marginal ice zone of the Eastern Beaufort Sea is analyzed to detect under-ice acoustic transients isolated from ambient noise with a dedicated algorithm. Noise transients due to ice cracking, fracturing, shearing, and ridging are sorted out into three categories: broadband impulses, frequency modulated (FM) tones, and high-frequency broadband noise. Their temporal and acoustic characteristics over the 8-month ice covered period, from November 2005 to mid-June 2006, are presented and their generation mechanisms are discussed.

Under-ice ambient noise in Eastern Beaufort Sea, Canadian Arctic, and its relation to environmental forcing.

This paper analyzes an 8-month time series (November 2005 to June 2006) of underwater noise recorded at the mouth of the Amundsen Gulf in the marginal ice zone of the western Canadian Arctic when the area was >90% ice covered. The time-series of the ambient noise component was computed using an algorithm that filtered out transient acoustic events from 7-min hourly recordings of total ocean noise over a [0-4.1] kHz frequency band.

[Case report: bilateral femoral and sciatic regional anesthesia in a polytraumatized patient].

Purpose: To present a case requiring regional anesthesia for both lower limbs, and to highlight the considerations to avoid potential local anesthetic toxicity, as a result of high cumulative doses of local anesthetic in this setting.

Clinical Features: A 32-yr-old, obese (body mass index = 30.4 kg.