Publications by authors named "Louis Cappelli"
Purpose Low-dose total skin electron beam therapy (LD-TSEBT) has recently gained popularity in treating mycosis fungoides (MF) due to its reduced toxicity and favorable response rates. Combining accelerated LD-TSEBT with the modified Stanford technique (mST), a condensed cycling approach, offers a promising and convenient option. However, in vivo dosimetry data confirming the effectiveness of this approach is limited.
View Article and Find Full Text PDFBackground: Many previous studies have investigated the prognostic value of body mass index (BMI) for GBM outcomes with varying results. We present a comprehensive literature review and meta-analysis investigating BMI as a prognostic value in GBM.
Methods: A systematic review of literature on adult patients with GBM published between 1999 and 2023 was conducted within OVID Medline, Pubmed, and Scopus.
Purpose: Uveal melanoma (UM) represents the most prevalent and aggressive intraocular malignancy in adults. This study examined the outcomes of patients diagnosed with high-risk UM who underwent fractionated stereotactic radiosurgery (fSRS) treatment utilizing a novel LINAC-based frameless technique.
Design: Retrospective, interventional case series.
Purpose: Glioblastoma (GBM) is the most common primary brain cancer in adults with a very poor prognosis. Metabolic drivers of tumorigenesis are highly relevant within the central nervous system, where glucose is the critical source of energy. The impact of obesity on survival outcomes in patients with GBM is not well established.
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- Local treatment options for recurrence of pancreatic adenocarcinoma are limited, with median survival times of 9-13 months, but MRI-guided stereotactic body radiation therapy (MRgSBRT) may improve outcomes by allowing higher radiation doses while protecting normal tissue.
- In a study involving 15 patients treated with MRgSBRT, the median overall survival after recurrence was 14.1 months, with local control rates of 92.3% and 83.9% at 6 and 12 months, respectively.
- The treatment showed manageable side effects, with 47% experiencing mild acute gastrointestinal toxicity and 31% facing chronic gastrointestinal issues, but no severe
Introduction: Iodine-125 (I-125) seeds, commonly used in low-dose rate brachytherapy for ocular malignancies, are often discarded after a single use. This study examines the potential cost savings at an institution with high ocular melanoma referrals, by re-using I-125 seeds for eye-plaque brachytherapy.
Methods: In this single-institutional retrospective analysis, data was collected from I-125 seed orders from 8/2019 through 10/2022.
Objective: Treatment of craniopharyngioma typically entails gross total resection (GTR) or subtotal resection with adjuvant radiation (STR-RT). We analyzed outcomes in adults with craniopharyngioma undergoing GTR versus STR-RT.
Methods: This retrospective study enrolled 115 patients with craniopharyngioma in 5 institutions.
Article Synopsis
- Radiation treatment has become the preferred option for uveal melanoma, moving away from the more invasive enucleation approach; a new frameless LINAC solution for fractionated stereotactic radiosurgery (fSRS) was developed to preserve the eye.
- A unique ocular localization box was created featuring adjustable LED lights for patient focus, eye position monitoring with a CCD camera, and tools to track eye movement, ensuring targeted and effective treatment sessions.
- Initial trials with 10 patients showed that the localization box was effective and well-tolerated, yielding high accuracy for positioning with minimal setup errors, paving the way for future trials to further assess its effectiveness and consistency in various settings.*
The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assessed circadian timing's impact on whole-brain radiotherapy outcomes in brain metastases for personalized cancer therapy insights. The aim of the study was to evaluate circadian influence on radiation treatment timing and its correlation with clinical outcomes and to identify patient populations benefiting from interventions synchronizing circadian rhythms, considering subgroup differences and potential disparities.
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- Gliomatosis cerebri (GC) is a rare and aggressive brain tumor that affects multiple lobes and is associated with a poorer prognosis compared to other gliomas, despite being classified differently under new WHO guidelines.
- The case study describes a 64-year-old male with GBM and extensive GC who responded well to treatment with tumor-treating fields (TTFields) combined with radiation and chemotherapy, showing significant improvement in his condition shortly after treatment.
- Though his glioma recurred 11 months after surgery, the aggressive GC remained under control, leading to a progression-free survival of 11 months and an overall survival of 17 months before his passing.
Article Synopsis
- Radiation therapy is crucial for treating glioblastoma (GBM), but it can cause scalp toxicity, affecting patient quality of life.
- This study compared traditional radiation techniques to a scalp-sparing volumetric modulated arc therapy (SSV) in GBM patients to see if it could minimize scalp radiation exposure while still effectively targeting the tumor.
- Results showed SSV significantly reduced doses to the scalp without affecting the radiation exposure to the tumor or surrounding critical structures.
Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite enormous research efforts, GBM remains a deadly disease. The standard-of-care treatment for patients with newly diagnosed with GBM as per the National Cancer Comprehensive Cancer Network (NCCN) is maximal safe surgical resection followed by concurrent chemoradiation and maintenance temozolomide (TMZ) with adjuvant tumor treating fields (TTF).
View Article and Find Full Text PDFHeterotopic ossification is the development of mature lamellar bone in soft tissues. Heterotopic ossification can occur in up to 23% of patients after amputation. Heterotopic ossification is often painful, causing significant dysfunction.
View Article and Find Full Text PDFThermoplastic masks are commonly used in radiation therapy to immobilize a patient's head and neck during treatment. They are primarily composed of non-toxic polyester compounds that can be manipulated with heat to mold the shape of a patient's head and neck. There is little previously reported evidence of these masks causing allergic contact dermatitis.
View Article and Find Full Text PDFTumor-to-tumor metastasis describes the ability of primary tumors to metastasize to other primary tumors. These events generally occur in aggressive and widely-metastatic disease, with the appropriate management and significance of these events unknown. A 56-year-old woman with a history of bilateral, localized, invasive lobular breast carcinoma treated with surgery, systemic therapy, and adjuvant radiation presented five and two years post-treatment with progressive neurological symptoms.
View Article and Find Full Text PDFStereotactic Radiosurgery for Poor Performance Status Patients.
Int J Radiat Oncol Biol Phys
July 2016
Purpose: Patients with poor performance status (PS), usually defined as a Karnofsky Performance Status of 60 or less, were not eligible for randomized stereotactic radiosurgery (SRS) studies, and many guidelines suggest that whole-brain radiation therapy (WBRT) is the most appropriate treatment for poor PS patients.
Methods And Materials: In this retrospective review of our SRS database, we identified 36 patients with PS of 60 or less treated with SRS for central nervous system (CNS) metastatic disease. PS, as defined by the Karnofsky Performance Status, was 60 (27 patients), 50 (8 patients), or 40 (1 patient).