Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies.

Acute severe ulcerative colitis (ASUC) occurs in up to 25% of patients with ulcerative colitis (UC). Therapeutic approaches have evolved during the past years with the increasing bio exposure of admitted patients and the extension of the number of approved drugs for UC. In this review, we aimed to summarize the latest evidence in short-term and long-term medical strategies for ASUC.

Making protocols available with the article improved evaluation of selective outcome reporting.

Objective: To compare primary outcomes reported in publications, protocols and registries and to evaluate the contribution of available protocols to assess selective outcome reporting (SOR) as compared with registration alone.

Study Design And Setting: We included all randomized controlled trials (RCTs) published in 2015 and 2016 in the five leading general medical journals. For each RCT, we evaluated whether the protocol was available and searched for registration.