Prognostic significance of Epstein-Barr virus (EBV) infection in Hodgkin lymphoma patients.

Introduction: The prognostic significance of Epstein-Barr virus (EBV) infection in Hodgkin lymphoma (HL) is still controversial. In this work we sought to examine the prognostic differences between EBV-positive and -negative HL through a series of 131 cases from Tunisia.

Methods: The status of EBV was assessed by EBV-encoded RNA (EBER) in situ hybridization.

Changing patterns in the Epstein-Barr virus (EBV)and Hodgkin lymphoma association in Tunisia.

We compared the features of the Epstein-Barr virus (EBV) and Hodgkin lymphoma (HL) association in Tunisia in two periods of time, 1991-2001 (111 cases) and 2002-2012 (122 cases). The investigation of the EBV status by EBER in situ hybridization showed a significant decrease in the prevalence of EBV-positive HL from 69.3 % for the period 1991-2001 to 40.

Investigation of miR9-1, miR9-2 and miR9-3 Methylation in Hodgkin Lymphoma.

Background: miR9 is an important tumor suppressor microRNA regulated by DNA methylation in various types of cancers.

Methods: We analyzed the methylation status of the 3 members of the miR9 family in 58 cases of Hodgkin lymphoma (HL) in comparison to 15 reactive lymph nodes. We also assessed the relationships between miR9 methylation and Epstein-Barr virus (EBV) infection and several clinicopathological parameters.

Anti-inflammatory and antiulcerogenic activities of leaf extracts and sesquiterpene from Teucrium ramosissimum (Lamiaceae).

Teucrium ramosissimum (Lamiaceae) is a native and endemic medicinal plant from South of Tunisia traditionally used for the treatment of many diseases. The anti-inflammatory and antiulcerogenic activities of sesquiterpene (β-eudesmol), chloroform, and ethyl acetate leaf extracts from T. ramosissimum were assayed.