Distributed Caregiving for Cognitively Impaired Individuals: A Case Report.

Many caregivers of people with cognitive impairment spend a significant amount of their time helping patients with instrumental daily functions. Distributed caregiving is an innovative model designed to reduce an individual caregiver's time burden and increase the likelihood of continued independent living for the patient. Echo Show and Google Home platforms were used to enable the participation of remote family members in caregiving, specifically the socialization and entertainment of a person with cognitive impairment.

Early clinical trials of chemopreventive and biologic agents: Designs, populations, and endpoints.

The optimal design for initial clinical trials of chemopreventive agents for cancer has not been determined. A single design is unlikely to be the model for chemoprevention of cancer, even for prevention of a single subtype of cancer, because of the heterogeneity of drugs under investigation and the variety of biologic effects being targeted. Factors that are important in designing initial clinical trials include the proposed mechanisms of drug action, the ability and types of assays available to detect that activity or pharmacodynamic effect, and the extent of prior clinical experience.

The effects of differing concentrations of bupivacaine on the epidural somatosensory evoked potential after posterior tibial nerve stimulation.

The somatosensory evoked potential (SEP) recorded from the cervical epidural space in response to stimulation of the posterior tibial nerve is often used to monitor spinal cord integrity during scoliosis surgery. Epidural analgesia may be used as part of the anesthetic technique for scoliosis surgery, but the effects of the local analgesic on the evoked potential must be determined to ensure that it does not interfere with the monitoring of spinal cord function. Therefore, we compared the effects of the administration of 10 mL of 0.

The regulation of phosphatidylcholine biosynthesis in rye (Secale cereale) roots. Stimulation of the nucleotide pathway by low temperature.

The incorporation of [14C]choline chloride and [14C]glycerol into segments taken from rye (Secale cereale L., cv. Rheidal) roots was greater in segments from roots grown at 5 degrees C than in segments taken from roots growing at 20 degrees C.

Transformation of phenoxyacetic acid herbicides by Phaseolus vulgaris L. callus cells.

The auxin herbicide (4-chloro-2-methylphenoxy)-acetic acid (MCPA) was absorbed by liquid cultured callus cells of Phaseolus vulgaris L. and subsequently became hydroxylated at the methyl group. The alcohol remained largely unconjugated and was partly released to the culture medium.

beta-D-Arabinofuran[1',2':4,5]oxazolo-1,3,5-triazine-5-N-methyl-4,6-dione and analogues, unusually specific immunosuppressive agents.

Sequential treatment of the protected beta-D-arabinofuran[1',2':4,5]-2-aminooxazoline (2) with methyl isocyanate and diimidazole carbonyl afforded the 2,2'-anhydro-beta-D-arabinofuranosyl nucleoside, 6. Deprotection and hydrolysis yielded the corresponding arabinoside. Although the anhydronucleoside exhibited in vitro antiviral activity against herpes simplex type 1, it exacerbated the infection in vivo.

Metabolic factors and the utilization of phosphorus by plants.

The overall process of entry and transport of phosphate by plants has been separated into its component parts. Rapid esterification is involved but a small proportion of the total transport may occur by a non-metabolic route. Mannose alters the metabolism of phosphate in roots of cereals and thereby reduces the transport to the shoot by as much as 99% whereas dicotyledonous species are much less sensitive.

Cyclitol glucosides and their role in the synthesis of a glucan from uridine diphosphate glucose in Phaseolus aureus. Characterization of some cyclitol glucosides and their synthesis.

Short-chained sugar compounds, thought to be involved in the synthesis of callose, were formed in small amounts from UDP-glucose by soluble extracts from hypocotyls of seedlings of Phaseolus aureus. The properties of the glycosides were investigated by treatment with various chemicals and analysis by paper chromatography, g.l.