Publications by authors named "Loudy P Priesterbach-Ackley"
Background: One targeted treatment option for isocitrate dehydrogenase ()-wild-type glioblastoma focuses on tumors with fibroblast growth factor receptor 3::transforming acidic coiled-coil-containing protein 3 () fusions. fusion detection can be challenging, as targeted RNA next-generation sequencing (NGS) is not routinely performed, and immunohistochemistry is an imperfect surrogate marker. Fusion status can be determined using reverse transcription polymerase chain reaction (RT-PCR) on fresh frozen (FF) material, but sometimes only formalin-fixed, paraffin-embedded (FFPE) tissue is available.
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- Molecular diagnostics plays a key role in caring for neuro-oncological patients by evaluating genetic and epigenetic factors.
- Various assays are used to detect different genetic alterations, from single gene tests to advanced techniques that can identify multiple abnormalities in one process.
- The review outlines the types of these molecular tests, highlighting their benefits and limitations in diagnosing central nervous system tumors.
Neurogenic tumors are the most common posterior mediastinal tumors in adults. Schwannomas originating from the recurrent laryngeal nerve are rare. The present study describes a 46-year-old man with a tumor in the left superior mediastinum.
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