Intensive conventional and insulin pump therapies in adult type I diabetes. A crossover study.

We examined the relative efficacy of two modes of insulin therapy in five patients with insulin-dependent diabetes. Using a crossover protocol, therapy with multiple insulin injections was compared with the use of continuous subcutaneous insulin infusion (pump therapy); both therapies were regulated by home blood glucose monitoring. Although both therapies were equally effective during 2 to 4 days of inpatient management, pump therapy was clearly superior in the outpatient setting.

Ocular toxoplasmosis in three consecutive siblings.

Ocular toxoplasmosis in consecutive siblings is rare. We report positive ocular and serologic findings in three consecutive teenaged siblings. Results of immunologic studies that were performed on members of the family failed to reveal deficiencies.

Biosynthesis of proteins by the retina. Inactivation by near-ultraviolet light and the effects of tryptophan, epinephrine, and catalase.

Postmitochondrial supernatant, cytosol, and microsomes were exposed to near-ultraviolet light and assayed for incorporation of (3H)leucine. The results indicate that near-ultraviolet light decreased the incorporation of radioactivity into the aminoacyl-tRNA fraction and into proteins. This effect depended on the wavelength of irradiation and the concentration of exposed protein.

Computed tomography of choroidal melanoma and scleral buckle.

In the investigation of a patient with choroidal melanoma in one eye and repaired rhegmatogenous retinal detachment in the other, a C.T. scan demonstrated the tumour in the right globe and the encircling silastic sponge around the left globe.

Successful treatment of Candida endophthalmitis with a synergistic combination of amphotericin B and rifampin.

Candida endophthalmitis, caused by transient candidemia, developed in a 14-year-old white girl receiving intravenous hyperalimentation. Antifungal synergism was established in vitro for the combination of amphotericin B and rifampin against the C. albicans isolate.