Publications by authors named "Lou Martineau"
J Infect Dis
November 2022
Article Synopsis
- About 1.1 million children are exposed to HIV antiretrovirals in utero, with potential safety concerns, particularly regarding integrase strand transfer inhibitor (InSTI) dolutegravir, which showed links to neural tube defects in infants.
- Researchers studied the impact of second-generation InSTIs on human embryonic stem cells and fetal development in pregnant mice, finding that at both subtherapeutic and therapeutic doses, some InSTIs caused negative effects like reduced cell counts and increased cell death.
- The findings stress the need for more research on the long-term safety and effects of InSTIs on embryonic development, especially as these drugs become more common among women of reproductive age.
