Publications by authors named "Lottie Phillips"
Article Synopsis
- The study explores the personal experiences of adult men with hypospadias, focusing on their identities and interpersonal relationships through in-depth interviews with 17 participants from diverse backgrounds.
- Four main categories of impact were identified: feelings of being different, challenges related to masculinity, personal experiences with sex and relationships, and issues surrounding family roles.
- The research highlights varying effects of hypospadias on life, from minor to significant, with critical periods like puberty influencing these experiences; it suggests that healthcare and support systems can improve overall well-being for individuals affected.
Background: Hypospadias is a common genital malformation among boys. Studies indicate that hypospadias is associated with a higher risk of testicular cancer. Other forms of urological cancer may be linked to hypospadias via a mutual aetiology, hormonal dysfunction, or hypospadias complications, but this has not yet been studied.
View Article and Find Full Text PDFObjectives: There is a lack of studies on men's individual experiences of living with hypospadias. We aimed to explore the personal experiences of having hypospadias in relation to healthcare and surgery.
Subjects And Methods: Purposive sampling was used to include men (aged 18 and over) with hypospadias representing different phenotypes (from distal to proximal) and ages in order to maximise the variation and richness of our data.
Background: Hypospadias is a common congenital malformation often related to the effect of androgens in utero. While hypogonadism is associated with many potential health risks including metabolic and cardiovascular disease, the risk of clinical hypogonadism and comorbidities in men with hypospadias later in life has not been studied.
Objectives: Investigate the risk of hypogonadism and somatic comorbidities in adolescents and men born with hypospadias.
Background: It is not known if impaired fertility in men with hypospadias is caused by decreased semen quality or other factors. Semen quality in men born with hypospadias may be impaired due to effects of androgens or testicular dysgenesis but has been very little studied.
Objectives: To study semen quality in men with hypospadias using dizygotic twinning rates as an epidemiological indicator.
In this study chemotherapy response in neuroblastoma (NB) was assessed for the first time in a transplantation model comprising non-malignant human embryonic microenvironment of pluripotent stem cell teratoma (PSCT) derived from diploid bona fide hESC. Two NB cell lines with known high-risk phenotypes; the multi-resistant BE(2)-C and the drug sensitive IMR-32, were transplanted to the PSCT model and the tumour growth was exposed to single or repeated treatments with doxorubicin, and thereafter evaluated for cell death, apoptosis, and proliferation. Dose dependent cytotoxic effects were observed, this way corroborating the experimental platform for this type of analysis.
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