-Induced Patterned Neurodegeneration Is Exacerbated by in .

Genetic and epidemiological studies have found that variations in the amyloid precursor protein () and the apoliopoprotein E () genes represent major modifiers of the progressive neurodegeneration in Alzheimer's disease (AD). An extra copy of or gain-of-function mutations in correlate with early onset AD. Compared to the other variants ( and ), the ε4 allele of () hastens and exacerbates early and late onset forms of AD.

Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron.

Neuronal activity often leads to alterations in gene expression and cellular architecture. The nematode Caenorhabditis elegans, owing to its compact translucent nervous system, is a powerful system in which to study conserved aspects of the development and plasticity of neuronal morphology. Here we focus on one pair of sensory neurons, termed URX, which the worm uses to sense and avoid high levels of environmental oxygen.

Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector.

Animal cytokinesis involves both actin-myosin-based contraction and vesicle-mediated membrane addition. In many cell types, including early embryos, Nuf/FIP3, a Rab11 effector, mediates recycling endosome (RE)-based vesicle delivery to the cytokinesis furrow. Nuf exhibits a cell cycle-regulated concentration at the centrosome that is accompanied by dramatic changes in its phosphorylation state.