Assessing predictors and outcomes of secondary debulking procedures in lower limb trauma reconstruction: A retrospective cohort study.

The goal of flap design in orthoplastic trauma is to provide stable, vascularized coverage for fractures, prevent infection and enable fracture union. This study aimed to improve orthoplastic trauma outcomes by identifying factors that predict the need for secondary flap debulking in severe open lower limb fractures. A retrospective cohort of 893 patients treated at a UK major trauma center was analyzed, with 126 patients (14.

The role of arginine, homoarginine and nitric oxide in pregnancy.

Normal pregnancy leads to profound maternal hemodynamic changes, including increased blood volume and vasodilatation. Several vasodilator mediators are implicated, including prostaglandins, carbon monoxide and nitric oxide (NO). Pre-eclampsia (PE) affects 3-10 % of pregnancies and is associated with increased maternal and perinatal morbidity and mortality.