Publications by authors named "Lotte B Christensen"
Aims: Rare variants in the glucokinase gene (GCK) cause Maturity-Onset Diabetes of the Young (MODY2/GCK-MODY). We investigated the prevalence of GCK variants, phenotypic characteristics, micro- and macrovascular disease at baseline and follow-up, and treatment among individuals with and without pathogenic GCK variants.
Methods: This is a cross-sectional study in a population-based cohort of 5,433 individuals without diabetes (Inter99 cohort) and in 2,855 patients with a new clinical diagnosis of type 2 diabetes (DD2 cohort) with sequencing of GCK.
Objective: Hyperglycaemia in type 2 diabetes is caused by varying degrees of two defects: low insulin sensitivity and beta-cell dysfunction. We assessed if subgrouping of patients into three pathophysiological phenotypes according to these defects could identify individuals with high or low risk of future cardiovascular events.
Design: This is a prospective cohort study.
Objective: To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.
Research Design And Methods: We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.
High birthweight may predispose children to acute lymphoid leukemia, whereas low birthweight is associated with childhood morbidity and mortality. Low and high birthweight have been inconsistently associated with mortality in children with leukemia. In a cohort of childhood and adolescent leukemia (0-19 years) patients from registries in Denmark, Norway, Sweden, and Washington State in the United States (1967-2015), five-year all-cause mortality was assessed by birthweight and other measures of fetal growth using the cumulative incidence function and Cox regression with adjustment for sex, diagnosis year, country, the presence of Down's syndrome or other malformations, and type of leukemia.
View Article and Find Full Text PDFBackground And Aims: When investigating and treating asthma in children, diagnosing must be precise and valid. There is a need for studies researching asthma in children showing how to use registry-based, epidemiological data. We examined the feasibility and validity of using anti-asthmatic drug prescription data to identify children with asthma and assessed medication patterns in children with and without confirmed asthma.
View Article and Find Full Text PDFAims: The aim of the study was to evaluate the incidence and causes of rehospitalisation within one year after percutaneous coronary intervention (PCI) in a country where the National Health Service provides universal tax-supported healthcare, guaranteeing residents free hospital access.
Methods And Results: Between January 2010 and September 2014, 17,111 patients were treated with PCI in two University Hospitals in Western Denmark. Patients who were readmitted within one year after PCI were identified.
Article Synopsis
- This study investigates the safety of stimulant medications (like methylphenidate and amphetamines) during pregnancy, focusing on their potential to cause congenital malformations in infants.
- It analyzed over 1.8 million pregnancies in the US and more than 2.5 million in Nordic countries from 2000 to 2013, noting the incidence of birth defects in infants exposed to stimulants during the first trimester.
- Results showed that while there was a slight increase in risk for congenital malformations with methylphenidate use, amphetamines did not show a significant risk, highlighting the need for cautious use of stimulants during pregnancy.
Background: Validation of definitions used to identify conditions of interest is imperative to epidemiologic studies based on routinely collected data. The objective of the study was thus to estimate positive predictive values (PPVs) of International Classification of Diseases, 10th Revision (ICD-10) codes to identify cases of incident acute pancreatitis leading to hospitalization and incident primary malignancy in the Scandinavian (Denmark, Norway, and Sweden) national patient registries in women with postmenopausal osteoporosis (PMO).
Methods: This validation study included postmenopausal (defined as 55 years or older) women with osteoporosis, identified between 2005-2014.
Background: Clinical epidemiology research studies, including pharmacoepidemiology and pharmacovigilance studies, use routinely collected health data, such as diagnoses recorded in national health and administrative registries, to assess clinical effectiveness and safety of treatments. We estimated positive predictive values (PPVs) of International Classification of Diseases, 10th revision (ICD-10) codes for primary diagnoses of dermatologic events and hypersensitivity recorded at hospitalization or emergency room visit in the national patient registries of Denmark and Sweden among women with postmenopausal osteoporosis (PMO).
Methods: This validation study included women with PMO identified from the Danish and Swedish national patient registries (2005-2014).
Introduction: In Denmark, 10% of the health budget is spent on treating chronic obstructive lung disease (COPD) and the economic burden from COPD looks more than likely to grow in the near future. With this in mind we initiated a pilot project with The Danish Lung association to discover early stages of COPD by using spirometry.
Material And Methods: A total of 344 persons from Aarhus and the surrounding area participated in a free anonymous walk-in spirometry project in the Health Centre, Aarhus.