Publications by authors named "Lotta Saustila"
Article Synopsis
- The EWSR1::CREM fusion gene results from a chromosomal translocation and is linked to various types of cancers, leading to a chimeric protein with unclear oncogenic mechanisms.
- Researchers studied the melanoma cell line CHL-1 and identified 712 altered genes after silencing EWSR1::CREM, revealing significant changes in cell cycle and migration pathways.
- One key finding was the downregulation of ODC1, an enzyme critical for cancer progression, suggesting that targeting ODC1 could be a promising new therapeutic approach for EWSR1::CREM-related tumors.
