Biophotonic sensors with integrated SiN-organic hybrid (SiNOH) lasers for point-of-care diagnostics.

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection. Within this context, waveguide-(WG)-based optical biosensors on the silicon-nitride (SiN) platform represent a particularly promising option, offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range. However, while passive SiN-based photonic circuits lend themselves to highly scalable mass production, the integration of low-cost light sources remains a challenge.

Lasing in SiN-organic hybrid (SiNOH) waveguides.

Silicon nitride (SiN) waveguides offer low-loss wave propagation over a wide spectral range including visible wavelengths and lend themselves to photonic integrated circuits for bio-photonic applications. The SiN device portfolio, however, is so far limited to passive devices that need to be fed by external light sources. This often requires delicate and costly fiber-chip coupling schemes that are subject to stringent alignment tolerances.

Configurable Resistive Response in BaTiO Ferroelectric Memristors via Electron Beam Radiation.

Ferroelectric oxide memristors are currently in the highlights of a thriving area of research aiming at the development of nonvolatile, adaptive memories for applications in neuromorphic computing. However, to date a precise control of synapse-like functionalities by adjusting the interplay between ferroelectric polarization and resistive switching processes is still an ongoing challenge. Here, it is shown that by means of controlled electron beam radiation, a prototypical ferroelectric film of BaTiO can be turned into a memristor with multiple configurable resistance states.

High-flexibility combinatorial peptide synthesis with laser-based transfer of monomers in solid matrix material.

Laser writing is used to structure surfaces in many different ways in materials and life sciences. However, combinatorial patterning applications are still limited. Here we present a method for cost-efficient combinatorial synthesis of very-high-density peptide arrays with natural and synthetic monomers.

Particle-Based Microarrays of Oligonucleotides and Oligopeptides.

In this review, we describe different methods of microarray fabrication based on the use of micro-particles/-beads and point out future tendencies in the development of particle-based arrays. First, we consider oligonucleotide bead arrays, where each bead is a carrier of one specific sequence of oligonucleotides. This bead-based array approach, appearing in the late 1990s, enabled high-throughput oligonucleotide analysis and had a large impact on genome research.

Effect of the silicone disclosing procedure on the shear bond strength of composite cements to ceramic restorations.

Statement Of Problem: There is no evidence-based information on how ceramic restorations with an adhesive bond between restoration material and composite cement may be influenced by a silicone disclosing agent.

Purpose: The aim of this study was to determine the effects of the silicone disclosing procedure on the shear bond strength of composite cements in the luting of industrial sintered and laboratory sintered ceramic restorations.

Material And Methods: Thirty standardized (15 x 10 x 9 mm) prefabricated ceramic specimens (Groups 1, 3, 5) and 30 standardized (15 x10 x 9 mm) conventionally sintered ceramic specimens (Groups 2, 4, 6) were roughened with sandpaper (800-grit).