Publications by authors named "Lotfi Miladi"

Article Synopsis
  • Spinal muscular atrophy (SMA2) is a severe neuromuscular disorder that can lead to spinal deformities like scoliosis, often requiring early surgical intervention when bracing is ineffective.
  • The study investigated changes in spinal and thigh muscles in SMA2 patients before and after a minimally invasive spinal surgery, involving MRI analysis for fat infiltration in muscle tissues.
  • Results showed increased fat infiltration in certain muscles post-surgery, but overall muscle involvement was significant in both preoperative and postoperative groups, while quality of life remained unaffected by these changes.
View Article and Find Full Text PDF

Introduction: Neuromuscular scoliosis (NMS) is associated with an abnormal muscle tone. Traditional conservative treatments, with the historical practice of early posterior fusion, have proven ineffective. Recently, growth-sparing techniques have gained traction owing to their ability to maximize trunk height.

View Article and Find Full Text PDF

Growing rod techniques are increasingly used for early-onset scoliosis in children. Unfortunately, they are associated with many complications, particularly neuromuscular scoliosis, favored by the poor general condition of these patients and the fragility of their osteoporotic bones. Furthermore, these interventions are often iterative and usually followed by vertebral fusion at the end of growth.

View Article and Find Full Text PDF

Pelvic fixation remains one of the main challenging issues in non-ambulatory neuromuscular scoliosis (NMS) patients, between clinical effectiveness and a high complication rate. The objective of this multicenter and retrospective study was to evaluate the outcomes of a technique that was applied to treat 173 NMS patients. The technique is not well-known but promising; it uses the ilio-sacral screw, combined with either the posterior spinal fusion or fusionless bipolar technique, with a minimum follow-up of two years.

View Article and Find Full Text PDF

Objectives: There are no established criteria for stiffness after fusionless surgery for neuromuscular scoliosis (NMS). As a result, there is no consensus regarding the surgical strategy to propose at long-term follow-up. This study reports the first use of shear wave elastography for assessing the mechanical response of lumbar intervertebral discs (IVDs) after fusionless bipolar fixation (FBF) for NMS and compares them with healthy controls.

View Article and Find Full Text PDF

Purpose: Lumbar kyphosis occurs in approximately 8-20% of patients with myelomeningocele (MMC). The purpose of this article is to analyze the risks and benefits of vertebrectomy and spinal stabilization in MMC children with severe lumbar kyphosis and to establish treatment guidelines.

Methods: This is an IRB-approved retrospective analysis of 59 patients with MMC who underwent kyphectomy and posterior instrumentation in three centers.

View Article and Find Full Text PDF

Study Design: Nonrandomized controlled cohort.

Objective: To compare early results between bipolar fusionless construct (BFC) and single posterior fusion (SPF) surgery in neuromuscular scoliosis (NMS).

Background: Surgical treatments for NMS have traditionally been characterized by high complication rates.

View Article and Find Full Text PDF

Study Design: Prospective cohort study.

Objectives: To report the results for an alternative technique based on minimally invasive fusion-less surgery. This approach is original in that it corrects deformities by proximal and distal fixation, with reliable pelvic fixation through the use of iliosacral screws on osteoporotic bones.

View Article and Find Full Text PDF
Article Synopsis
  • Early Onset Scoliosis (EOS) is a serious spinal condition in children that can progress and potentially threaten their health, leading to the development of "growth-friendly" surgical techniques like traditional growing rods and newer devices.
  • Recent advancements include the Spring Distraction System (SDS) and One Way Self-Expanding Rod (OWSER), which aim to address limitations of current methods.
  • The ongoing BiPOWR trial will compare the effectiveness and safety of the SDS and OWSER in treating neuromuscular EOS over one year, with key outcomes measured such as spinal growth and patient quality of life.
View Article and Find Full Text PDF
Article Synopsis
  • * A study compared 140 patients who underwent either PSF or MIFS from 2012 to 2017, analyzing factors such as age, preoperative preparation, postoperative complications, and recovery period.
  • * Results showed that while both techniques achieved similar spinal corrections, the PSF group experienced significantly more complications, including higher rates of infection and blood transfusion needs compared to the MIFS group.
View Article and Find Full Text PDF
Article Synopsis
  • Pelvic fixation in neuromuscular scoliosis patients is challenging due to their weak bone quality, but this study evaluates the effectiveness of ilio-sacral screw fixation.
  • The study analyzed 167 patients who underwent a surgical technique using minimally invasive bipolar fixation with ilio-sacral screws, showing significant reductions in pelvic obliquity and coronal curve angle post-operation.
  • The findings revealed a lower complication rate compared to previous reports, with most patients achieving stable results over an average follow-up period of more than 6 years.
View Article and Find Full Text PDF
Article Synopsis
  • Growth-preserving spinal surgery has a high complication rate, but a new bipolar instrumentation method shows promise with lower rates; however, its biomechanics need further study.
  • This research aims to combine lab tests and real-life data to create a finite element model (FEM) of the spine, comparing the performance of bipolar vs. traditional all-screw implants.
  • Experimental results indicated that the FEM closely matched real measurements, suggesting that both bipolar and all-screw designs exhibit similar stress levels and could be useful for treating neuromuscular scoliosis in children.
View Article and Find Full Text PDF

Background: Treatment of spinal muscular atrophy (SMA) scoliosis has evolved in the last decade, with the emergence of fusionless surgical techniques that allow correction of the deformity before the end of growth spurt. These techniques are expected to delay definitive spine fusion and preserve trunk growth.

Purpose: The aim was to evaluate long-term clinical, radiologic, and respiratory outcomes of a minimally invasive fusionless surgery (MIFLS) in SMA scoliosis.

View Article and Find Full Text PDF

The widely used treatment of early onset scoliosis based on fusionless spinal instrumentation with growing rods suffers from severe complications due to premature rod failure. Only few studies have explored the fracture mechanisms in single rod constructs, while clinical practice urgently needs guidance. The objectives of this study are (i) to determine the failure mechanisms in Ti-6Al-4V alloy, Ti Cp 2 and Co-Cr alloy rods, and (ii) to propose strategies to reduce the risk of rod fracture.

View Article and Find Full Text PDF

Study Design: A prospective study.

Objective: The aim of this study was to report the results of an alternative technique to growing rods (GR) for neuromuscular scoliosis using a minimally invasive fusionless surgery with a minimum of 5 years' follow-up.

Summary Of Background Data: Conservative treatment is not effective in progressive neuromuscular scoliosis.

View Article and Find Full Text PDF

Purpose: Progressive early-onset scoliosis raises major challenges for surgeons, as growth must be preserved. With traditional growing rods, the need for repeated surgery is associated with numerous complications, high costs, and heavy psychosocial burden on the patient and family. We assessed the safety and efficacy of a new one-way self-expanding rod (OWSER).

View Article and Find Full Text PDF

Ilio-sacral screw fixation for treatment of spinal deformities with pelvic obliquity was used from more than 40 years in our department of pediatric orthopedics. Despite trying all the other systems published in the literature, the authors came back to iliosacral screw to address the pelvic fixation. Keeping the same anatomical and biomechanical principles, with no damage of the SI joint, they improve the technology over time, to allow an easy use.

View Article and Find Full Text PDF

Objective: Early-onset scoliosis (EOS) is not uncommon in patients with neurofibromatosis type 1 (NF1). Despite conservative treatment, spinal deformities progress and require early surgical intervention. To avoid potential interference with chest and trunk growth, growing rods (GRs) have been used effectively in EOS of various etiologies.

View Article and Find Full Text PDF

Study Design: Retrospective case series.

Objectives: To analyze the outcomes at skeletal maturity of patients treated with a single traditional growing rod (GR). To compare results of patients according to whether posterior spinal fusion (PSF) was performed at treatment completion.

View Article and Find Full Text PDF
Article Synopsis
  • This study evaluated a new minimally invasive fusionless surgery for spinal deformities in patients with neuromuscular diseases.
  • The procedure involved a special double rod system anchored to the pelvis using iliosacral screws, achieving significant corrections in spinal alignment and pelvic obliquity over time.
  • Results showed a 61% improvement in Cobb angle and an 83% correction in pelvic obliquity, with manageable complications, demonstrating the technique's safety and effectiveness for preserving spinal growth.
View Article and Find Full Text PDF

Background: Classic Rett Syndrome (RS) is a disabling condition mainly caused by MECP2 mutations. Girls with RS are at risk of developing bone fragility and fractures at a young age which results in pain and may seriously impair quality of life.

Objective: To retrospectively assess the safety and efficacy of IV bisphosphonates on fracture, bone mineral density (BMD) and bone markers in RS girls with bone fragility.

View Article and Find Full Text PDF

Purpose: Anterior fusion is a well-established procedure for the treatment of Lenke 5C adolescent idiopathic scoliosis (AIS). This retrospective study aimed to assess preoperative and postoperative radiographic differences between the conventional anterior fusion and anterior short fusions (ASF) in Lenke 5C AIS.

Methods: Radiographic data of 42 consecutive cases of Lenke 5C AIS, which were surgically treated through anterior segmental fusion, were analyzed retrospectively.

View Article and Find Full Text PDF

Purpose: Acute pancreatitis is a possible complication after scoliosis surgery. Although some risk factors have been documented in the literature, clinical description of pancreatitis diagnosis and ensuing course still remain very poor. The aim of this study was to describe characteristics of acute pancreatitis after scoliosis surgery.

View Article and Find Full Text PDF

The porcine model is frequently used during development and validation of new spinal devices, because of its likeness to the human spine. These spinal devices are frequently composed of pedicle screws with a reputation for stable fixation but which can suffer pullouts during preclinical implantation on young animals, leading to high morbidity. With a view to identifying the best choices to optimize pedicle screw fixation in the porcine model, this study evaluates ex vivo the impact of weight (age) of the animal, the level of the vertebrae (lumbar or thoracic) and the type of screw anchorage (mono- or bi-cortical) on pedicle screw pullouts.

View Article and Find Full Text PDF