Publications by authors named "Lotan Cooper"

Article Synopsis
  • Pediatric urolithiasis is rare and usually linked to specific anatomical or metabolic issues, with this study examining emergency department (ED) admissions for renal colic among children and its potential relationship with climate.
  • A retrospective analysis of ED visits from 2010 to 2020 found a total of 609 admissions, showing a general decline over the years, with peaks in 2012 and 2018.
  • The research concluded that, unlike adults, seasonal variations and climate changes did not influence renal colic admissions in children, indicating different factors may be at play in this younger demographic.
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Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model of AD, in regard to BBB function.

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Galectin-1 has been implicated in the process of vertebrate developmental regulation. Sodium butyrate is an established differentiation-inducing agent and has been shown to increase galectin-1 expression in colon carcinoma cells. We studied the roles of butyrate and galectin-1 in the induction of differentiation and apoptosis in the prostate cancer cell line LNCaP.

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We have analyzed the expression of galectin-1 and galectin-3 in four human prostate carcinoma cell lines. Northern analysis and immunoblotting experiments showed that three cell lines express both galectins. However, only galectin-1 was detected on the surface of these cells.

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