Impacts of maternal separation stress on ethanol intake and endocannabinoid system in adolescent mice.

Clinical and preclinical studies suggest that early life stress can increase the risk of developing ethanol use disorder later in life. Although the endocannabinoid (eCB) system plays a role in stress-related behaviors and ethanol consumption, it remains unclear whether the eCB system is affected in response to a combination of both factors. By using male and female adolescent C57BL/6J mice subjected to a maternal separation (MS) stress paradigm from postnatal day (PND) 1 to 14, we explored (1) the consequences of early life stress experiences on ethanol consumption in adolescent mice and (2) how these events affect the eCB system and neuronal activation in brain regions associated with the reward system.

Seismic loss assessment of direct-DBD platform-type cross-laminated timber shear wall systems using FEMA P-58 methodology.

An efficient design method should provide practitioners with a means for sizing timber buildings to meet specific performance levels against estimated earthquake intensities. Displacement and energy design considerations in force-based design (FBD) procedures are not as precise as intended in complex systems, such as mid- to high-rise timber buildings. The main aim of this study is to tailor the direct displacement-based design (D-DBD) classical framework to platform-type cross-laminated timber (CLT) shear wall structural systems and validate their performance for low-rise to high-rise timber mixed-use buildings.

Lateral vibration data of an 18-story timber-concrete hybrid building obtained by on-site vibration tests.

The dataset provided in this paper includes the lateral vibration data obtained by on-site vibration tests on an 18-story timber-concrete hybrid building, which was completed in 2017 and is located within the University of British Columbia campus in Vancouver, Canada. Aiming at evaluating vibration properties such as natural periods, damping ratios, and mode shapes, microtremor measurement (i.e.

Experimental campaign on the mechanical properties of Canadian small clear spruce-pine-fir wood: Experimental procedures, data curation, and data description.

This article contains an experimental dataset related to the mechanical properties of Canadian small clear spruce-pine-fir wood. Motivated by the necessity of shading light on the orthotropic mechanical behavior of clear specimens of two of the most common wooden grades used for the manufacturing of cross-laminated timber panels in North America, a comprehensive experimental campaign on small clear spruce-pine-fir wood specimens, based on ASTM D143-22, has been conducted in the Department of Wood Science of the University of British Columbia. A total of 690 specimens from both visually-graded number 2 and machine-stress rated 2100fb 1.

Effect of patients' attitude and perception of oral hygiene on white spot lesion development and plaque accumulation during orthodontic treatment : A survey of patients with fixed appliances.

Purpose: To explore the impact of oral hygiene practices, as well as beliefs and attitudes toward orthodontic treatment on white spot lesion (WSL) development and plaque accumulation in orthodontic patients.

Materials And Methods: A total of 106 individuals (61 female, 45 male) patients aged 10-49 years who were treated with fixed appliances treatment completed a 14-question survey regarding aspects of their oral hygiene (OH) and orthodontic visits. The number of teeth with WSL and the plaque indexes were recorded for each patient.

Veterinarians should understand what it means to use conditionally approved drugs, with a focus on conditional approval of companion animal oncology drugs.

The purpose of this article is to provide veterinarians with an understanding of what it means to use a conditionally approved drug. This article summarizes information that has been used to satisfy the reasonable expectation of effectiveness (RXE) standard for conditionally approved companion animal oncology drugs and compares that standard to the substantial evidence of effectiveness (SEE) standard. For conditional approval, the drug company must establish a RXE but need not demonstrate SEE.

Maternal Separation Stress Affects Voluntary Ethanol Intake in a Sex Dependent Manner.

Maternal separation (MS) stress is a predictive animal model for evaluating the effects of early stress exposure on alcohol use disorders (AUD). The extended amygdala (AMY) is a complex circuit involved in both stress- and ethanol-related responses. We hypothesized that MS stress may increase ethanol consumption in adulthood, as well as augment neuronal activity in extended AMY, in a sex-dependent manner.

Lipid-based formulations to increase cannabidiol bioavailability: In vitro digestion tests, pre-clinical assessment and clinical trial.

Herein, medium-chain triglycerides (MCT), glyceryl monolinoleate (GML), and a self-emulsifying drug delivery system (SEDDS) for cannabidiol (CBD) delivery were compared using in vitro and in vivo (mouse and human) studies. In vitro digestion tests showed that SEDDS yielded the highest CBD recovery in the aqueous phase (86 ± 2%), followed by GML (13 ± 2%) and MCT (5.6% ± 0.

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental disorders that cause high levels of functional disabilities. Also, the currently available therapies for these disorders are limited. Therefore, the search for treatments that could be beneficial for the altered course of the neurodevelopment associated with these disorders is paramount.

Textile Antenna for Bio-Radar Embedded in a Car Seat.

A bio-radar system is presented for vital signs acquisition, using textile antennas manufactured with a continuous substrate that integrates the ground plane. Textile antennas were selected to be used in the RF (Radio Frequency) front-end, rather than those made of conventional materials, to further integrate the system in a car seat cover and thus streamline the industrial manufacturing process. The development of the novel substrate material is described in detail, as well as its characterization process.

Blockade of GluN2B-containing NMDA receptors reduces short-term brain damage induced by early-life status epilepticus.

Status epilepticus (SE) during developmental periods can cause short- and long-term consequences to the brain. Brain damage induced by SE is associated to NMDA receptors (NMDAR)-mediated excitotoxicity. This study aimed to investigate whether blockade of GluN2B-containing NMDAR is neuroprotective against SE-induced neurodegeneration and neuroinflammation in young rats.

Safety evaluation of supratherapeutic dose of Maytenus ilicifolia Mart. ex Reissek extracts on fertility and neurobehavioral status of male and pregnant rats.

Maytenus ilicifolia Mart. ex Reissek is a plant commonly used in folklore medicine in the management of gastric diseases in South America. This study explores the effects of a supratherapeutic dose of aqueous and ethanol extracts of M.

Smart Coat with a Fully-Embedded Textile Antenna for IoT Applications.

The Internet of Things (IoT) scenario is strongly related with the advance of the development of wireless sensor networks (WSN) and radio frequency identification (RFID) systems. Additionally, in the WSN context, for a continuous feed, the integration of textile antennas for energy harvesting into smart clothing is a particularly interesting solution when the replacement of batteries is not easy to practice, such as in wearable devices. This paper presents the E-Caption: Smart and Sustainable Coat.

Perception of chemesthetic stimuli in groups who differ by food involvement and culinary experience.

In the English language, there is generally a limited lexicon when referring to the sensations elicited by chemesthetic stimuli like capsaicin, allyl isothiocyanate, and eugenol, the orally irritating compounds found in chiles, wasabi, and cloves, respectively. Elsewhere, experts and novices have been shown to use language differently, with experts using more precise language. Here, we compare perceptual maps and word usage across three cohorts: experts with formal culinary education, naïve individuals with high Food Involvement Scale (FIS) scores, and naïve individuals with low FIS scores.

Influence of environmental enrichment vs. time-of-day on behavioral repertoire of male albino Swiss mice.

Environmental enrichment (EE) is a non-pharmacological manipulation that promotes diverse forms of benefits in the central nervous system of captive animals. It is thought that EE influences animal behavior in a specie-(strain)-specific manner. Since rodents in general present different behaviors during distinct periods of the day, in this study we aimed to investigate the influence of time-of-day on behavioral repertoire of Swiss mice that reared in EE.

Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice.

Background And Purpose: Caffeine (a non-selective adenosine receptor antagonist) prevents memory deficits in aging and Alzheimer's disease, an effect mimicked by adenosine A2 A receptor, but not A1 receptor, antagonists. Hence, we investigated the effects of adenosine receptor agonists and antagonists on memory performance and scopolamine-induced memory impairment in mice.

Experimental Approach: We determined whether A2 A receptors are necessary for the emergence of memory impairments induced by scopolamine and whether A2 A receptor activation triggers memory deficits in naïve mice, using three tests to assess short-term memory, namely the object recognition task, inhibitory avoidance and modified Y-maze.

It tastes as good as it looks! The effect of food presentation on liking for the flavor of food.

Diners in a restaurant were served the same meal (composed of a sautéed chicken breast with a fines herbes sauce, brown rice pilaf, and sautéed green beans with toasted almonds served on a round white china plate). The same food was presented in two different arrangements on two different nights. Although the two presentations were judged as equally "neat", one was judged as more attractive.

Topographical analysis of reactive zinc in the central nervous system of adult zebrafish (Danio rerio).

Reactive zinc (Zn) is crucial for neuronal signaling and is largely distributed within presynaptic vesicles of some axon terminals of distinct vertebrates. However, the distribution of reactive Zn throughout the central nervous system (CNS) is not fully explored. We performed a topographical study of CNS structures containing reactive Zn in the adult zebrafish (Danio rerio).

Low-intensity physical training recovers object recognition memory impairment in rats after early-life induced Status epilepticus.

When it occurs early in life, Status epilepticus (SE) can cause behavioural and cognitive impairments in adulthood. Here, we evaluated the putative benefits of low-intensity treadmill training on long-standing cognitive impairment in rats submitted to SE early in life. Wistar rats were submitted to LiCl-pilocarpine-induced SE at P16.

Textile materials for the design of wearable antennas: a survey.

In the broad context of Wireless Body Sensor Networks for healthcare and pervasive applications, the design of wearable antennas offers the possibility of ubiquitous monitoring, communication and energy harvesting and storage. Specific requirements for wearable antennas are a planar structure and flexible construction materials. Several properties of the materials influence the behaviour of the antenna.