Biomimetic cardiac tissue chip and murine arteriovenous fistula models for recapitulating clinically relevant cardiac remodeling under volume overload conditions.

Cardiovascular events are the primary cause of death among dialysis patients. While arteriovenous fistulas (AVFs) are the access of choice for hemodialysis patients, AVF creation can lead to a volume overload (VO) state in the heart. We developed a three-dimensional (3D) cardiac tissue chip (CTC) with tunable pressure and stretch to model the acute hemodynamic changes associated with AVF creation to complement our murine AVF model of VO.

Drosophila yakuba - Tsc1.

Gene Model for the ortholog of in the DyakCAF1 assembly (GCA_000005975.1).

Drosophila yakuba - Tsc1.

Gene Model for in the 's DyakCAF1 assembly (GCA_000005975.1).

Treatment of keratoconjunctivitis sicca with Elmiron.

Ten women with primary Sjögren's syndrome were treated with sodium pentosan polysulfate (Elmiron) 150 mg X 2 daily for 4 months in an open investigation. No subjective or objective improvement was recorded.