Preventing diabetes in the clinical setting.

Objective: Translating lessons from clinical trials on the prevention or delay of type 2 diabetes to populations in nonstudy settings remains a challenge. The purpose of this paper is to review, from the perspective of practicing clinicians, available evidence on lifestyle interventions or medication to prevent or delay the onset of type 2 diabetes.

Design: A MEDLINE search identified 4 major diabetes prevention trials using lifestyle changes and 3 using prophylactic medications.