Publications by authors named "Lorreta Yun-Tien Lin"

Development of novel biodosimetry assays and medical countermeasures is needed to obtain a level of radiation preparedness in the event of malicious or accidental mass exposures to ionizing radiation (IR). For biodosimetry, metabolic profiling with mass spectrometry (MS) platforms has identified several small molecules in easily accessible biofluids that are promising for dose reconstruction. As our microbiome has profound effects on biofluid metabolite composition, it is of interest how variation in the host microbiome may affect metabolomics based biodosimetry.

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This review focuses on early discoveries that contributed to our understanding and the scope of transcriptional responses after radiation damage. Before the development of modern approaches to assess overall global transcriptomic responses, the idea that mammalian cells could respond to DNA-damaging agents in a manner analogous to bacteria was not generally accepted. To investigate this possibility, the development of technology to identify differentially expressed low-abundance transcripts substantially facilitated our appreciation that DNA damaging agents like UV radiation and subsequently ionizing radiation did in fact produce robust transcriptional responses.

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Article Synopsis
  • Several diagnostic tools are being developed to help respond to radiological or nuclear emergencies, focusing on using biofluid small-molecule signatures to indicate tissue damage from radiation exposure.
  • A study using genetically modified mice showed varying immune responses and how these could impact biodosimetry models for dose reconstruction after radiation exposure.
  • The research identified specific metabolites in urine and serum that successfully distinguished between different radiation doses, indicating these biomarkers could be reliable for assessing radiation damage, even in immunosuppressed individuals.
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