Publications by authors named "Lorraine Greffe"
Background: We have been intrigued by the observation that aortic stenosis (AS) may be associated with characteristic features of mitral drug-induced valvular heart disease (DI-VHD) in patients exposed to valvulopathic drugs, thus suggesting that beyond restrictive heart valve regurgitation, valvulopathic drugs may be involved in the pathogenesis of AS.
Methods: Herein are reported echocardiographic features, and pathological findings encountered in a series of patients suffering from both AS (mean gradient >15mmHg) and mitral DI-VHD after valvulopathic drugs exposure. History of rheumatic fever, chest radiation therapy, systemic disease or bicuspid aortic valve disease were exclusion criteria.
Article Synopsis
- The study investigates mechanical dyssynchrony in patients with heart failure with preserved ejection fraction (HFpEF) and compares it to various control groups, including those with reduced ejection fraction and hypertensive controls.
- Researchers used advanced echocardiography techniques to assess dyssynchrony in 160 patients, finding that indices of dyssynchrony in HFpEF patients were similar to hypertensive controls and those with reduced ejection fraction but a narrow QRS duration.
- The results suggest that mechanical dyssynchrony does not play a significant role in HFpEF, raising doubts about the effectiveness of cardiac resynchronization therapy (CRT) for these patients.