Publications by authors named "Lorraine D Buckberry"
Article Synopsis
- A novel monoclonal antibody was developed by immunizing mice with colorectal tumor cell lines and was found to bind specifically to a cell surface antigen prevalent in most colorectal tumors.
- The antibody, SC104, targets a specific sialyltetraosylceramide antigen, selectively expressed on various tumors, including esophageal and gastric cancers, with minimal presence in normal tissues.
- Notably, SC104 induces tumor cell death through a classic apoptotic pathway independently of immune cells, highlighting its potential for therapeutic use alongside other treatments like chemotherapy.
