Publications by authors named "Lorraine Colon-Cartagena"
Article Synopsis
- A new AI model was developed for diagnosing invasive lobular carcinoma (ILC) in breast cancer, using CDH1 biallelic mutations as a reliable genetic ground truth instead of subjective histologic features.
- The model demonstrated high accuracy in predicting these mutations (95%) and diagnosing ILC (96%), with additional insights into other mechanisms of CDH1 inactivation found in some samples.
- Validation across various patient cohorts supported the model's effectiveness (accuracy of 0.95 and 0.89), showcasing the potential of using genetic data to improve AI diagnostics in pathology.
Article Synopsis
- CDH1 (E-cadherin) inactivation is commonly seen in invasive lobular carcinoma (ILC), leading to its unique cell structure, but some ILCs do not show this genetic alteration and have unexplored genetic causes.* -
- In a study of 364 ILCs, researchers found 25 cases without CDH1 bi-allelic changes, often associated with frequent CDH1 promoter methylation and some cases involving mutations in the AXIN2 gene.* -
- Further analysis revealed that in ILCs without typical CDH1 alterations, changes in other genes related to cell adhesion (like AXIN2 and CTNND1) contribute to their characteristics, suggesting these ILC
Melanoma differentiation associated gene-9 (MDA-9), Syntenin-1, or syndecan binding protein is a differentially regulated prometastatic gene with elevated expression in advanced stages of melanoma. MDA-9/Syntenin expression positively associates with advanced disease stage in multiple histologically distinct cancers and negatively correlates with patient survival and response to chemotherapy. MDA-9/Syntenin is a highly conserved PDZ-domain scaffold protein, robustly expressed in a spectrum of diverse cancer cell lines and clinical samples.
View Article and Find Full Text PDFBackground: Reducing the rate of margin positivity and reoperations remains a paramount goal in breast-conserving surgery (BCS). This study assesses the effectiveness of standard partial mastectomy with cavity shave margins (CSM) compared with partial mastectomy with selective margin resection (SPM), with regard to outcomes of the initial surgeries, re-excisions, and overall costs.
Patients And Methods: This is a retrospective review of 122 eligible breast cancer patients who underwent BCS at one institution.