A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide; it develops in a relatively symptom-free manner, leading to rapid disease progression and metastasis, leading to a 5-year survival rate of less than 5%. A lack of dependable diagnostic markers and rapid development of resistance to conventional therapies are among the problems associated with management of the disease. A better understanding of pancreatic tumour biology and discovery of new potential therapeutic targets are important goals in pancreatic cancer research.

Implementation challenges of a renal nursing professional practice model.

A city-wide steering-committee developed and introduced a program wide renal nursing professional practice model (PPM) using a variety of strategies. The PPM outlines values, practice guidelines, professional relationships, and the care delivery model. Challenges are inherent when implementing changes on multiple sites amidst a city-wide merger.